Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.6/1116
Título: Development of new biomaterials with antibacterial properties for future application in regenerative medicine
Outros títulos: Desenvolvimento de novos biomateriais com propriedades antibacterianas para futuras aplicações em medicina regenerativa
Autor: Vieira, Tânia Sofia dos Santos
Palavras-chave: Infecção bacteriana
Escherichia coli
Mecanismo antibacteriano
Nanopartículas de prata
Nanopartículas de quitosano
Nanopartículas de dextrano
Nanotecnologia
Data de Defesa: Jun-2012
Editora: Universidade da Beira Interior
Resumo: Bacterial infections have been a constant threat to human health throughout the history. Bacterial colonization of biomedical devices and implants causes enormous problems for healthcare systems worldwide, costs and increases patient’s suffering. Silver has been known, since the antiquity, by their antimicrobial properties and was used to produce reservoirs of food and with medical purposes. With the development of nanotechnology, silver nanoparticles have attracted the attention of different researchers due to their properties, as antimicrobial properties and high surface to volume ratio. However, these nanoparticles can form aggregates, which have toxic effects to the human cells. Recently, silver nanoparticles have been stabilized with several polymers and surfactants in order to avoid these problems. In this work, silver nanoparticles were produced and stabilized with chitosan/dextran. The produced nanoparticles were characterized by Scanning Electron Microscopy, Ultraviolet-Visible and Fourier Transform Infrared spectroscopy. Furthermore, the antibacterial activity of the produced nanoparticles was evaluated and it was found that they are effective in the prevention of the growth of Escherichia coli through a minimum inhibitory concentration. These particles were also studied in contact with human osteoblast cells in order to ascertain if the particles that had an antibacterial effect to the bacteria do not have a toxic effect for human cells. The results herein obtained revealed that the nanoparticles can be used in a near future as a coating material of medical devices in order to avoid their bacterial colonization.
Peer review: yes
URI: http://hdl.handle.net/10400.6/1116
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