Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.6/2311
Título: Cyclooxygenase-2 immunoexpression in breast cancer : progesterone receptor influence
Autor: Almeida, Micaela Carina Pereira
Orientador: Moutinho, José Alberto Fonseca
Muñoz Moreno, Javier
Palavras-chave: Cancro da mama
Cancro da mama - Ciclooxigenase 2
Cancro da mama - Receptor de progesterona
Cancro da mama - Receptor de estrogénio
Data de Defesa: 2010
Resumo: In breast cancer cyclooxygenase-2 expression is related with high local estrogen receptor levels and consequent poor outcomes, but the clinical relevance of cyclooxygenase-2 is still unclear. We analyzed, by immunostaining, cyclooxygenase-2 and progesterone receptor expression in 31 cases of women with invasive ductal carcinoma, from Child and Women department of Cova da Beira Medical Center. Cyclooxygenase-2 and progesterone receptor expression was observed in 64.5% and 54.8% of the tumors, respectively. We verified that tumors with progesterone receptor expression had lower size and the majority of women with these tumors had no axillary node metastasis, when compared to tumors with positive progesterone receptor. Similar results were found when a correlation between progesterone receptor, cyclooxygenase-2 and clinicopathological factors was performed. These results suggest that progesterone receptor has a protective role in breast cancer by inflammatory pathway modulation. COX-2+/PR+ seems to be a marker of better behavior in ductal invasive breast cancer. We speculate if cyclooxygenase-2 determination may have be a clinical usefulness in clinical practice. It’s expected that further studies may clarify this issue.
URI: http://hdl.handle.net/10400.6/2311
Designação: Mestrado em Ciências Biomédicas
Aparece nas colecções:FCS - DCM | Dissertações de Mestrado e Teses de Doutoramento

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