Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.6/558
Título: Pyridazine derivatives. XI: Antihypertensive activity of 3-hydrazinocycloheptyl[1,2-C]pyridazine and its hydrazone derivatives
Autor: Gil-Longo, José
Laguna, Maria de los Reyes
Verde, Ignacio
Castro, Maria Elena
Orallo, Francisco
Fontenla, José Angel
Calleja, José Maria
Ravina, Enrique
Teran, Carmen
Data: 28-Abr-2010
Resumo: 3-Hydrazinocycloheptyl[1,2-c]pyridazine (4) and its hydrazone derivatives 3-[N1-(isopropylidene)]hydrazinocycloheptyl[1,2-c]pyridazine [correction of hydrazinocyclohexyl] (5) and 3-[N1-(isobutylidene)]hydrazinocycloheptyl[1,2-c]pyridazine (6) were prepared, and their activity against genetic, neurogenically-induced, and deoxycorticosterone acetate -NaCl-induced hypertension was found to be at least as great as that of hydralazine. The results of studying vasorelaxation of rat aorta by 4 and hydralazine suggest that both these compounds owe their antihypertensive activity to direct relaxation of vascular smooth muscle.
URI: http://hdl.handle.net/10400.6/558
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