Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.6/3904
Título: Study of atopic markers in allergic rhinitis in the elderly
Autor: Monteiro, Joana Gonçalves
Orientador: Lourenço, Olga Maria Marques
Palavras-chave: Rinite alérgica
Rinite alérgica - Atopia
Rinite alérgica - Marcadores atópicos
Imunoglobulina E (Ige)
Imunoglobulina G (Igg)
Data de Defesa: 2011
Resumo: Allergic rhinitis (AR) is a prevalent disease worldwide, affecting 10% to 25% of the world population. AR’s prevalence has increased during the past few decades. Rhinitis is defined as an inflammation of the nasal mucosa and is characterized by one or more of the following symptoms: congestion, rhinorrhea, itching of the nose, postnasal drip, and sneezing. Atopy is known to increase the risk of developing allergic disorders such as AR; this is the tendency to produce the IgE antibody in response to low doses of aeroallergens. The aim of this study was to evaluate atopy through different methods in an elderly population in Covilhã. The population of this study consisted in two groups of individuals of Beira Interior: one of young adults (born between January 1976 and December 1993) and another of elderly (born before 1944). A standardised questionnaire was carried out in all volunteers. In addition, they were evaluated by three commonly used approaches: Skin Prick Tests (SPT), total serum IgE and Phadiatop. The study sample included 403 volunteers. Although all patients answered the questionnaire, only 381 patients were evaluated for SPT reaction to 5 common regional aeroallergens and only 356 accepted to collect blood for total IgE and Phadiatop determination. Data analysis was based on Phadiatop results. Among the 356 random subjects involved, 239 were elderly (mean age = 73; 141 females) and 117 were young adults (mean age= 28; 70 females). Of these, 96 volunteers (38 elderly and 58 young adults) had positive Phadiatop and 48 (21 elderly and 27 young adults) had positive SPT. Furthermore, significant differences were found on both groups, concerning to academic degree, social class and residence. This study suggests that elderly subjects are less atopic than younger subjects in the population under study. In both groups atopy prevalence according to Phadiatop, was higher in men; a significant correlation was found between Phadiatop positivity and positive SPT. In what concerns total IgE, no significant relation exists between was found on its concentration values and volunteers’ age. AR was defined with positive Phadiatop and presence of disease symptoms. 69 volunteers had AR (42 young adults and 27 elderly). Of those, elderly are more sensitized to outdoor allergens than young adults and less sensitized to indoor allergens, but not significantly. Overall, the population that has positive TCA for outdoor allergens feels like pollen season increases their symptoms. With this study was possible to conclude that AR has a higher prevalence on young adults and affects more men in both groups.
URI: http://hdl.handle.net/10400.6/3904
Designação: Mestrado em Bioquímica
Aparece nas colecções:FC - DQ | Dissertações de Mestrado e Teses de Doutoramento

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