Cernadas, Maria TeresaPereira, JoãoMelo, Bruna Daniela Lopesde Melo-Diogo, DuarteCorreia, Ilídio Joaquim SobreiraAlves, PatríciaCalvinho, Paula Cristina Nunes Ferreira2025-10-022025-10-022024-10-17Cernadas, T., Pereira, J., Melo, B. L., de Melo-Diogo, D., Correia, I. J., Alves, P., & Ferreira, P. (2024). Renewable Photo-Cross-Linkable Polyester-Based Biomaterials: Synthesis, Characterization, and Cytocompatibility Assessment. Biomacromolecules, 25(11), 7134-71451526-4602http://hdl.handle.net/10400.6/18939TThe present work consist of the synthesis of photo-crosslinkable materials, based on unsaturated polyesters (UPs), synthesized from biobased monomers from renewable sources such as itaconic acid and 1,4- butanediol. The UPs were characterized to assess the influence of polycondensation reaction temperature and cross-linking time on their final properties. For this purpose, different UV irradiation exposure periods were tested. Homogeneous, uniform, and transparent films were obtained after 1, 3, and 5 min of UV exposure. These cross-linked films were then characterized. All materials presented high gel content, which was dependent on the reaction’s temperature. The thermal behaviors of the UPs were shown to be similar. In vitro hydrolytic degradation tests showed that the materials can undergo degradation in phosphate-buffered saline (PBS) at pH 7.4 and 37 °C, ensuring their biodegradability over time. Finally, to assess the applicability of the polyesters as biomaterials, their cytocompatibility was determined by using human dermal fibroblasts.engBiomaterials Degradation Materials Nucleic acid structure Organic polymersresearch articlehttps://doi.org/10.1021/acs.biomac.4c00599