Gil-Longo, JoséLaguna, Maria de los ReyesVerde, IgnacioCastro, ElenaOrallo, FranciscoFontenla, Jose A.Calleja, José MariaRavina, EnriqueTerán, Carmen2010-04-282010-04-281993http://hdl.handle.net/10400.6/5583-Hydrazinocycloheptyl[1,2-c]pyridazine (4) and its hydrazone derivatives 3-[N1-(isopropylidene)]hydrazinocycloheptyl[1,2-c]pyridazine [correction of hydrazinocyclohexyl] (5) and 3-[N1-(isobutylidene)]hydrazinocycloheptyl[1,2-c]pyridazine (6) were prepared, and their activity against genetic, neurogenically-induced, and deoxycorticosterone acetate -NaCl-induced hypertension was found to be at least as great as that of hydralazine. The results of studying vasorelaxation of rat aorta by 4 and hydralazine suggest that both these compounds owe their antihypertensive activity to direct relaxation of vascular smooth muscle.journal article