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LodrupPalosuo, KatiSoto-Martinez, ManuelPanaitescu, CarmenKvedarienė, VioletaPanzner, P.Braido, FulvioTsiligianni, IoannaRodriguez-Gonzalez, MonicaScichilone, NicolaCanonica, Giogio WalterPassalacqua, GiovanniRomantowski, JanUrrutia-Pereira, MarilynFilho, Nelson Augusto RosarioOllert, Markus W.Rottem, MenachemChkhartishvili, EkaterineSova, MilanValovirta, ErkkaMohammad, YousserSperl, AnnetteWilliams, SiânSpranger, OttoNeffen, HugoStelmach, RafaelBurte, EmilieValentin Rostan, MarylinPark, Hae-SimVan Ganse, EricVan Hage, MariannePitsios, ConstantinosVasankari, TuulaLinnemann, Désirée LarenasLoureiro, Cláudia ChavesSagara, HironoriWorm, MargittaYiallouros, PanayiotisYusuf, OsmanZaitoun, FaresBonini, MatteoHrubiško, MartinCingi, C.Dykewicz, MarkZernotti, MarioCalderon, MoisesHalpin, David M.G.Zidarn, MihaelaPatella, VincenzoSheikh, AzizZuberbier, JaronPapadopoulos, NikolaosLouis, RenaudSuppli Ulrik, CharlotteFonseca, João P.Zuberbier, TorstenAnto, Josep M.Costa, ElisioEiwegger, ThomasBosnic-Anticevich, SinthiaCruz, AlvaroSousa, Jaime Correia deLouis-Philippe, BouletErhola, MarinaCardona, VictoriaCarr, WarnerGemicioglu, BilunPawankar, RubyFokkens, WytskeCalvo, MárioGarcia-Aymerich, J.Mäkelä, Mika J.Hofmann, Maja AnnKlimek, LudgerMakris, MichaelMohamed Sayed, ZeinabMaurer, MarcusD'Amato, G.Momas, IsabelleSiroux, ValérieAlmeida, Mário MoraisCorrigan, ChrisMullol, JoaquimMontefort, StephenJutel, MarekPham Thi, NhanHossny, ElhamAkdis, MubeccelPfaar, OliverVentura, Maria TeresaRegateiro, Frederico S.Bindslev-Jensen, CarstenRing, JohannesBustamante, MarionaPinto, Bernardo SousaKaidashev, IgorGuerra, StefanoStandl, MarieSunyer, J.Keil, ThomasBarata, Luís TabordaCamargos, PauloWeiss, ScottNaclerio, RobertYorgancıoglu, ArzuZhang, LuoNadeau, KariAbdul Latiff, Amir2023-04-212023-04-212023http://hdl.handle.net/10400.6/13302Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one-airway-one-disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis.engAsthmaToll-like receptorsMultimorbidityRhinitisIL-33journal article10.1111/all.15679