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Abstract(s)
A cafeína é a substância psicostimulante mais consumida a nível mundial, estando
estabelecida no dia a dia de grande parte da população; o que, pela sua natureza
estimulante, possui diversos efeitos no corpo humano. A nível cardiovascular e de forma
mais macroscópica, esta substância já foi associada ao aumento do risco de doença
coronária, enfarte agudo do miocárdio, arritmias, entre outras variantes patológicas.
Contudo os mecanismos moleculares e celulares associado a estes efeitos nefastos a nível
cardiovasculares continuam sobre intensa investigação, como o seu efeito na contração
muscular, na fisiologia do cálcio, a sua influência nos recetores de rianodina tipo 2 e nos
mecanismos de repolarização. Neste sentido, o objetivo desta dissertação será fazer uma
revisão de literatura sobre os efeitos moleculares e celulares da cafeína nos
cardiomiócitos, de maneira a explorar como tudo se processa intricadamente a um nível
mais microscópico, que posteriormente poderão a vir originar os mais sobejamente
conhecidos outcomes cardiovasculares supramencionados.
Caffeine is the most consumed psychostimulant substance worldwide, remaining in the day-to-day life of a large part of the population, which, due to its stimulating nature, has several effects on the human body. At a cardiovascular level and more macroscopically, this substance has already been associated with an increased risk of coronary disease, acute myocardial infarction, arrhythmias, among other pathological variants. However, the molecular and cellular movements associated with these harmful effects at the cardiovascular level remain under intense investigation, such as their effect on muscle contraction, calcium physiology, their influence on type 2 ryanodine receptors and on repolarization movements. Regarding this, the objective of this dissertation will be to carry out a literature review on the molecular and cellular effects of caffeine on cardiomyocytes, to explore how everything is intricately processed at a more microscopic level, which may subsequently lead to the most well-known cardiovascular outcomes mentioned above.
Caffeine is the most consumed psychostimulant substance worldwide, remaining in the day-to-day life of a large part of the population, which, due to its stimulating nature, has several effects on the human body. At a cardiovascular level and more macroscopically, this substance has already been associated with an increased risk of coronary disease, acute myocardial infarction, arrhythmias, among other pathological variants. However, the molecular and cellular movements associated with these harmful effects at the cardiovascular level remain under intense investigation, such as their effect on muscle contraction, calcium physiology, their influence on type 2 ryanodine receptors and on repolarization movements. Regarding this, the objective of this dissertation will be to carry out a literature review on the molecular and cellular effects of caffeine on cardiomyocytes, to explore how everything is intricately processed at a more microscopic level, which may subsequently lead to the most well-known cardiovascular outcomes mentioned above.
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Keywords
Cafeína Cálcio Cardiomiócitos Miocárdio Retículo Sarcoplasmático