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Advisor(s)
Abstract(s)
O presente relatório de estágio encontra-se subdividido em três capítulos. O primeiro
capítulo diz respeito à revisão sistemática sobre os inibidores da 11ß-hidroxiesteróide
desidrogenase tipo 1 (11ß-HSD1) no tratamento da Diabetes Mellitus Tipo 2. A diabetes
é uma patologia cada vez mais frequente na sociedade, tornando-se numa das
principais causas de morte em todo o mundo. Por este motivo, novos alvos terapêuticos
têm vindo a ser estudados. A 11ß-HSD1 é uma enzima que se expressa primariamente
no fígado e tecido adiposo e é responsável pela redução da cortisona à sua forma ativa
cortisol que, consequentemente, pode levar a alterações metabólicas, como a
resistência à insulina e hiperglicemia. Desta forma, a inibição da 11ß-HSD1 pode
constituir uma nova abordagem terapêutica para a Diabetes Mellitus Tipo 2. Com este
trabalho pretende-se rever sistematicamente a evidência científica disponível acerca
deste tópico. Para tal, foi realizada uma pesquisa em três bases de dados e através dos
quais foram incluídos 15 artigos neste estudo. Apesar dos altos níveis inibitórios que
esta classe apresenta no fígado e tecido adiposo, os estudos até agora publicados não
têm demonstrado resultados comercialmente atrativos em populações diabéticas. Além
disso, os efeitos dos inibidores da 11ß-HSD1 a longo prazo carecem de ensaios clínicos.
Porém, esta enzima continua a ser um alvo promissor para o desenvolvimento de
fármacos neste âmbito, especialmente devido à sua eficácia no controlo dos vários
fatores que constituem a síndrome metabólica e ao seu potencial para múltiplas
indicações em doentes com diabetes, incluindo a cicatrização de feridas e a perda de
peso.
O segundo capítulo relata a experiência adquirida durante o estágio curricular em
farmácia hospitalar no Centro Hospitalar Universitário da Cova da Beira (CHUCB).
Aqui são descritas as diferentes áreas que tive a oportunidade de acompanhar, bem
como as diversas funções e atividades que o farmacêutico aí desempenha.
O terceiro capítulo é referente ao estágio em farmácia comunitária, realizado na
Farmácia Matias Pereira. Aqui, é apresentado globalmente todo o funcionamento da
farmácia comunitária e a legislação que regula o setor, assim como as tarefas realizadas
durante o estágio.
The present dissertation is divided in three chapters. The first one refers to the systematic review about the 11ß-HSD1 inhibitors in type 2 diabetes mellitus treatment. Diabetes is a pathology more and more frequent in society, becoming one of the main causes of death worldwide. For this reason, new therapeutic targets have been studied. 11ß-HSD1 is an enzyme that is expressed primarily in liver and adipose tissue and is responsible for reducing cortisone to its active form cortisol which, consequently, can lead to metabolic changes such as insulin resistance and hyperglycaemia. In this way, the inhibition of 11ß-HSD1 may offer a new therapeutic approach for type 2 diabetes mellitus. This work intends to systematically review the available scientific evidence on this topic. To this end, a search was conducted in three databases and through which 15 articles were included in this study. Despite the high inhibitory levels that these drugs have in liver and adipose tissue, the studies published so far have not shown commercially attractive results in diabetic populations. In addition, the long-term effects of 11ß-HSD1 inhibitors require long-term clinical trials. However, this enzyme remains a promising target for drug development, especially due to its effectiveness in controlling the various factors that constitute the metabolic syndrome and its potential for multiple indications in patients with diabetes, including wound healing and weight loss. The second chapter reports on the experience acquired during the curricular internship in hospital pharmacy at CHUCB. Here are described the different areas that I had the opportunity to follow, as well as the various functions and activities that the pharmacist performs there. The third chapter refers to the internship in community pharmacy, held at Farmácia Matias Pereira. Here, the entire operation of the pharmacy and the legislation that regulates the sector are presented globally, as well as the tasks performed during the internship.
The present dissertation is divided in three chapters. The first one refers to the systematic review about the 11ß-HSD1 inhibitors in type 2 diabetes mellitus treatment. Diabetes is a pathology more and more frequent in society, becoming one of the main causes of death worldwide. For this reason, new therapeutic targets have been studied. 11ß-HSD1 is an enzyme that is expressed primarily in liver and adipose tissue and is responsible for reducing cortisone to its active form cortisol which, consequently, can lead to metabolic changes such as insulin resistance and hyperglycaemia. In this way, the inhibition of 11ß-HSD1 may offer a new therapeutic approach for type 2 diabetes mellitus. This work intends to systematically review the available scientific evidence on this topic. To this end, a search was conducted in three databases and through which 15 articles were included in this study. Despite the high inhibitory levels that these drugs have in liver and adipose tissue, the studies published so far have not shown commercially attractive results in diabetic populations. In addition, the long-term effects of 11ß-HSD1 inhibitors require long-term clinical trials. However, this enzyme remains a promising target for drug development, especially due to its effectiveness in controlling the various factors that constitute the metabolic syndrome and its potential for multiple indications in patients with diabetes, including wound healing and weight loss. The second chapter reports on the experience acquired during the curricular internship in hospital pharmacy at CHUCB. Here are described the different areas that I had the opportunity to follow, as well as the various functions and activities that the pharmacist performs there. The third chapter refers to the internship in community pharmacy, held at Farmácia Matias Pereira. Here, the entire operation of the pharmacy and the legislation that regulates the sector are presented globally, as well as the tasks performed during the internship.
Description
Keywords
Controlo Glicémico Cortisol Diabetes Mellitus Tipo 2 Farmácia Comunitária Farmácia Hospitalar Inibidores da 11ß-Hsd1 Revisão Sistemática