Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.6/4691
Título: 3D scaffolds coated with nanofibers displaying bactericidal activity for bone tissue applications
Autor: Sá, Kevin Domingos de
Figueira, Daniela Sofia Rodrigues
Miguel, Sónia Alexandra Pereira
Correia, Tiago Ruivo
Silva, Abílio Manuel Pereira da
Correia, Ilídio Joaquim Sobreira
Palavras-chave: Bactericidal activity
Bone regeneration
Electrospinning
Rapid prototyping
Salicylic acid
Silver nanoparticles
Data: 10-Set-2016
Editora: Taylor & Francis
Citação: De Sá, K. D., Figueira, D. R., Miguel, S. P., Correia, T. R., Silva, A. P., e Correia, I. J. (2017) “3D Scaffolds Coated with Nanofibers Displaying Bactericidal Activity for Bone Tissue Applications.” International Journal of Polymeric Materials and Polymeric Biomaterials, Vol.66 (9), pp.432-442
Resumo: Bone-limited capacity to fully repair large defects requires the development of new implants. In this context, new approaches have been used to promote bone regeneration and also to avoid the side effects associated with the therapeutics currently used in the clinic. Herein, 3D tricalcium phosphate/alginic acid scaffolds were produced and then coated with an electrospun mesh loaded with two different antibacterial agents, silver nanoparticles, and salicylic acid. The obtained results showed that the produced scaffolds have suitable mechanical properties, swelling, biodegradation, biomineralization activity, enhanced cellular adhesion/proliferation and bactericidal activity, and features essential for bone regeneration.
Peer review: yes
URI: http://hdl.handle.net/10400.6/4691
DOI: 10.1080/00914037.2016.1236338
Versão do Editor: https://www.tandfonline.com/doi/abs/10.1080/00914037.2016.1236338
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