Browsing by Author "Castro, Maria Elena"
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- 5-HT2 antagonist activity of 3-aminomethyltetralonesPublication . Verde, Ignacio; Loza, M.; Castro, Maria Elena; Orallo, Francisco; Fontenla, José Angel; Calleja, José Maria; Ravina, Enrique; Cortizo, L.; Deceballos, M. L.The affinity of four 3-aminomethyltetralones for 5-HT2 receptors is reported, together with their inhibitory activity against serotonin-induced contractions in rat aorta rings stripped of endothelium. Compound 4, which has a p-fluorobenzoyl-piperidine fragment, exhibited activity similar to that of methysergyde.