Browsing by Author "Costa, Gabriel Flor Alves Rodrigues Barreira da"
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- Design and characterization of Ta and Sr ion doped tricalcium phosphate bioceramicPublication . Costa, Gabriel Flor Alves Rodrigues Barreira da; Silva, Abílio Manuel Pereira da; Winiecki, Mariusz; Fernandes, Natanael Filipe FerreiraWith the aging population, challenges in bone regeneration are becoming more frequent, creating the need for effective alternatives that improve well-being. A common solution is the use of metallic materials, such as titanium and stainless steel, in orthopedic and dental implants. However, these materials, despite their mechanical and biological qualities, can undergo ionic exchange (corrosion) and cause adverse reactions in tissues, such as metallosis. To mitigate these problems, the use of ceramics, such as tricalcium phosphate (TCP), has been explored as a substitute or metallic coating. TCP is valued for its bioactive, osteoinductive, and resorbable properties, facilitating osteoconduction. Doping TCP with metallic ions, such as strontium and tantalum, is an enhancement that promotes the function of osteoblasts, inhibits bone resorption, and increases mechanical strength and biocompatibility. In this work, samples of TCP doped with tantalum, strontium, and both were developed to evaluate their performance as bone substitutes and coatings. The characterization of the bioceramics demonstrates that the compositions exhibit promising properties. The incorporation of Sr alone significantly enhances the mechanical strength, increasing it from 7.6 MPa to 12.9 MPa. Additionally, the combined incorporation of Ta and Sr increases porosity from 24% to 34%, while maintaining cell viability close to 100% across all compositions. Furthermore, it is confirmed that all compositions are suitable for producing bioceramic coatings on titanium substrates.