UBIMEDICAL
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O UBIMEDICAL compreende 2 áreas distintas: a área laboratorial e a área de incubação. A área laboratorial tem a missão de suporte e transferência de tecnologia, e compreende um conjunto de laboratórios residentes coordenados por docentes da UBI nas áreas da saúde e ciências da vida. A incubadora acolhe empreendedores e empresas inovadoras nas mesmas áreas.
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Percorrer UBIMEDICAL por Domínios Científicos e Tecnológicos (FOS) "Ciências Médicas::Ciências da Saúde"
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- Bioactive Potential of Wild Plants from Gardunha Mountain: Phytochemical Characterization and Biological ActivitiesPublication . Coimbra, Alexandra; Gallardo, Eugenia; Luís, Ângelo; Gaspar, Pedro Dinis; Ferreira, Susana; Duarte, Ana Paula; Adriana, IrinelThe plants used in folk medicine have been increasingly studied to identify their bioactive properties. Therefore, this study aimed to assess the bioactivity of the hydroethanolic extracts of plants collected in Gardunha Mountain, Portugal. Seven abundant and representative wild plants were studied: , , , , , , and . The phytochemical composition of the extracts was determined by UHPLC-timsTOF-MS and by spectrophotometric methods. The antioxidant, in vitro anti-inflammatory and antimicrobial activity and the biocompatibility of the extracts were tested. The extracts were predominantly composed of flavonoids and phenolic acids, such as gallic acid, neochlorogenic acid and quercetin glycosides. The extracts demonstrated very strong antioxidant activity related to scavenging free radicals (AAI = 2.84 and 2.93). Regarding antimicrobial activity, the extract exhibited inhibitory effects, particularly against Gram-positive bacteria and yeasts (MIC = 0.008-0.5 mg/mL). The , , and extracts showed low cytotoxicity (viability > 70%) in the highest concentration tested. These findings highlight and as promising sources of novel bioactive compounds, particularly antimicrobials in controlling microbial growth and promoting associated health benefits, and underscore the value of traditional medicinal plants as a guide for pharmacological studies.
- Production and Characterization of a Pullulan-Based Facial Mask Incorporating Grape Seed Flour Extract for Cosmeceutical ApplicationsPublication . Ferreira, Ester; Encarnação, Bárbara; Cascalheira, José Francisco; Ferreira, Susana; Ramos, Ana; Luís, Ângelo; Gallardo, Eugenia; Domingues, Fernanda; Magni, ChiaraThis study aimed to develop and characterize an eco-friendly facial mask based on the pullulan biopolymer incorporating grape seed flour extract, a sustainable source of polyphenols. The extract was characterized by its phenolic content, antioxidant capacity, enzyme inhibition and antimicrobial activity. High total phenolic and flavonoid contents, along with the presence of -resveratrol, conferred strong antioxidant activity. The extract effectively inhibited tyrosinase and elastase enzymes, indicating its anti-aging potential, and exhibited antimicrobial effects particularly against . The incorporation of the extract in pullulan films increased thickness and coloration while maintaining transparency and improving barrier properties. The bioactive films showed strong antioxidant activity and displayed selective antibacterial activity against , including MRSA strains. A facial mask prototype was successfully produced, demonstrating flexibility, solubility, and potential for topical applications. Overall, the developed pullulan-grape seed extract films exhibit multifunctional cosmeceutical potential combining antioxidant, antimicrobial, and anti-aging effects with sustainable valorization of wine industry by-products.