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Functionalization of polydimethylsiloxane membranes to be used in the production of voice prostheses

2013-09-27Journal article Restricted access
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dc.contributor.authorFerreira, Paula
dc.contributor.authorCarvalho, Álvaro
dc.contributor.authorCorreia, Tiago R.
dc.contributor.authorAntunes, Bernardo Paiva
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.contributor.authorAlves, Patrícia
dc.date.accessioned2018-03-20T09:07:29Z
dc.date.available2018-03-20T09:07:29Z
dc.date.issued2013-09-27
dc.description.abstractThe voice is produced by the vibration of vocal cords which are located in the larynx. Therefore, one of the major consequences for patients subjected to laryngectomy is losing their voice. In these cases, a synthetic one-way valve set (voice prosthesis) can be implanted in order to allow restoration of speech. Most voice prostheses are produced with silicone-based materials such as polydimethylsiloxane (PDMS). This material has excellent properties, such as optical transparency, chemical and biological inertness, non-toxicity, permeability to gases and excellent mechanical resistance that are fundamental for its application in the biomedical field. However, PDMS is very hydrophobic and this property causes protein adsorption which is followed by microbial adhesion and biofilm formation. To overcome these problems, surface modification of materials has been proposed in this study. A commercial silicone elastomer, SylgardTM 184 was used to prepare membranes whose surface was modified by grafting 2-hydroxyethylmethacrylate and methacrylic acid by low-pressure plasma treatment. The hydrophilicity, hydrophobic recovery and surface energy of the produced materials were determined. Furthermore, the cytotoxicity and antibacterial activity of the materials were also assessed. The results obtained revealed that the PDMS surface modification performed did not affect the material's biocompatibility, but decreased their hydrophobic character and bacterial adhesion and growth on its surface.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFerreira, P., Carvalho, A., Correia, T.R., Antunes, B.P., Correia, I.J. e Alves, P. (2013) "Functionalization of polydimethylsiloxane membranes to be used in the production of voice prosthesis", Science and Technology of Advanced Materials, Vol. 14(5), nº do artigo 055006pt_PT
dc.identifier.doi10.1088/1468-6996/14/5/055006pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4638
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relationIsolation and Purification of Plasmid DNA for Cancer Therapy
dc.relation.publisherversionhttps://www.tandfonline.com/doi/full/10.1088/1468-6996/14/5/055006pt_PT
dc.subjectPolydimethylsiloxanept_PT
dc.subjectVoice prosthesispt_PT
dc.subjectPlasma surface modificationpt_PT
dc.subjectCell adhesionpt_PT
dc.titleFunctionalization of polydimethylsiloxane membranes to be used in the production of voice prosthesespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleIsolation and Purification of Plasmid DNA for Cancer Therapy
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEME-TME%2F103375%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FEBB-BIO%2F114320%2F2009/PT
oaire.citation.startPage055006pt_PT
oaire.citation.titleScience and Technology of Advanced Materialspt_PT
oaire.citation.volume14pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876-PPCDTI
person.familyNameCristina Nunes Ferreira Calvinho
person.familyNameCorreia
person.familyNameJoaquim Sobreira Correia
person.familyNameAlves
person.givenNamePaula
person.givenNameTiago
person.givenNameIlídio
person.givenNamePatrícia
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-idA119-FFB8-0899
person.identifier.ciencia-id491D-AA5E-FBC0
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id341B-551C-19FD
person.identifier.orcid0000-0003-3393-4427
person.identifier.orcid0000-0002-4077-4698
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0002-8943-8329
person.identifier.ridI-1004-2013
person.identifier.scopus-author-id55321888200
person.identifier.scopus-author-id55670188900
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id12762379800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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