Publication
A study of glaucine-induced relaxation of rat aorta
| dc.contributor.author | Verde, Ignacio | |
| dc.contributor.author | Orallo, Francisco | |
| dc.contributor.author | Loza, Isabel | |
| dc.contributor.author | Gil-Longo, José | |
| dc.contributor.author | Calleja, José Maria | |
| dc.contributor.author | Cadavid, Isabel | |
| dc.date.accessioned | 2010-04-28T10:06:46Z | |
| dc.date.available | 2010-04-28T10:06:46Z | |
| dc.date.issued | 1993 | |
| dc.description.abstract | The vasorelaxant effect of glaucine, the major alkaloid of Platycapnos spicata (L.) Bernh., was studied. At concentrations of 10 microM-0.3 mM in normal Krebs solution it was almost equieffective in relaxing K(+)-induced and noradrenaline-induced tension in rat aortic rings without endothelium, with IC50 values of 160 +/- 16 microM and 90 +/- 14 microM respectively. In experiments in a calcium-free medium, 10 microM glaucine strongly inhibited noradrenaline-induced contractions. Glaucine (0.3 mM) did not affect basal uptake of 45Ca, but induced uptake was reduced to 100% (K+) and 97.7% (noradrenaline) of the basal value. These results suggest that glaucine has an intracellular effect and also acts on the cell membrane by blocking voltage-dependent and receptor-operated calcium channels. | |
| dc.identifier.uri | http://hdl.handle.net/10400.6/545 | |
| dc.language.iso | eng | pt |
| dc.title | A study of glaucine-induced relaxation of rat aorta | pt |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 59:229-31 | pt |
| oaire.citation.title | Planta Medica | pt |
| person.familyName | Verde | |
| person.givenName | Ignacio | |
| person.identifier.ciencia-id | D012-1D7C-791A | |
| person.identifier.orcid | 0000-0003-3492-5725 | |
| person.identifier.rid | M-3991-2013 | |
| person.identifier.scopus-author-id | 55913729400 | |
| rcaap.rights | openAccess | pt |
| rcaap.type | article | pt |
| relation.isAuthorOfPublication | bfb58284-b817-4267-9628-8fa150aa681c | |
| relation.isAuthorOfPublication.latestForDiscovery | bfb58284-b817-4267-9628-8fa150aa681c |
Files
Original bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- t00593pdf.pdf
- Size:
- 211.93 KB
- Format:
- Adobe Portable Document Format