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Microneedle-based delivery devices for cancer therapy: a review

2019Journal article Open access
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dc.contributor.authorMoreira, André
dc.contributor.authorRodrigues, Ana Carolina Félix
dc.contributor.authorJacinto, Telma A.
dc.contributor.authorMiguel, Sónia
dc.contributor.authorCosta, Elisabete
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2019-09-03T13:48:07Z
dc.date.available2021-09-03T00:30:11Z
dc.date.issued2019
dc.description.abstractMacroscale delivery systems that can be locally implanted on the tumor tissue as well as avoid all the complications associated to the systemic delivery of therapeutics have captured researchers' attention, in recent years. Particularly, the microneedle-based devices can be used to efficiently deliver both small and macro-molecules, like chemotherapeutics, proteins, and genetic material, along with nanoparticle-based anticancer therapies. Such capacity prompted the application of microneedle devices for the development of new anticancer vaccines that can permeate the tumor tissue and simultaneously improve the effectiveness of therapeutic agents. Based on the promising results demonstrated by the microneedle systems in the local administration of anticancer therapeutics, this review summarizes the different microneedle formulations developed up to now aimed for application on cancer therapy (mphasizing those produced with polymers). Additionally, the microneedles' general properties, type of therapeutic approach and its main advantages are also highlighted.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.doi10.1016/j.phrs.2019.104438pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/7214
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
dc.relation3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
dc.relationDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
dc.subjectMicroneedlespt_PT
dc.subjectCancerpt_PT
dc.subjectVaccinespt_PT
dc.subjectGene deliverypt_PT
dc.subjectChemotherapypt_PT
dc.titleMicroneedle-based delivery devices for cancer therapy: a reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
oaire.awardTitle3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
oaire.awardTitleDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109482%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F103507%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109563%2F2015/PT
oaire.citation.conferencePlaceHolandapt_PT
oaire.citation.startPage104438pt_PT
oaire.citation.titlePharmacological Researchpt_PT
oaire.fundingStream5876
oaire.fundingStreamPOR_CENTRO
oaire.fundingStreamPOR_CENTRO
person.familyNameMoreira
person.familyNameFélix Rodrigues
person.familyNameAndrade Jacinto
person.familyNamePereira Miguel
person.familyNameda Rocha Costa
person.familyNameJoaquim Sobreira Correia
person.givenNameAndré Ferreira
person.givenNameAna Carolina
person.givenNameTelma Maria
person.givenNameSónia Alexandra
person.givenNameElisabete Cristina
person.givenNameIlídio
person.identifier1161643
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person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-id3D14-BE84-E5CD
person.identifier.ciencia-id2717-B57C-9AD7
person.identifier.ciencia-id1A13-ABC0-C32C
person.identifier.ciencia-idB314-4CF0-6633
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0002-5493-8331
person.identifier.orcid0000-0002-0135-2126
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0002-0490-0095
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id57202076016
person.identifier.scopus-author-id57205459390
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id55805850100
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctOs direitos do artigo foram cedidos à editorapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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