Repository logo
 
Publication

Characterization and evaluation of Achillea erba-rotta subsp. moschata (Wulfen) I. Richardson and Achillea millefolium L. as potential ingredients for skin applications

2025-06-09Journal article Restricted access
Simple item page
datacite.subject.fosCiências Médicas
dc.contributor.authorMarengo, Arianna
dc.contributor.authorCagliero, Cecilia
dc.contributor.authorSgorbini, Barbara
dc.contributor.authorMenzio, Giulia
dc.contributor.authorFusani, Pietro
dc.contributor.authorDuarte, Ana Paula
dc.contributor.authorLuís, Ângelo Filipe Santos
dc.contributor.authorFonseca, Lara R. S.
dc.contributor.authorFeijó, Mariana Pombal
dc.contributor.authorSocorro, Sílvia
dc.contributor.authorBertea, Cinzia Margherita
dc.contributor.authorRubiolo, Patrizia
dc.date.accessioned2025-08-25T13:27:43Z
dc.date.available2025-08-25T13:27:43Z
dc.date.issued2025-06-09
dc.description.abstractEthnopharmacological relevance: Despite their different geographical distribution Achillea millefolium L. and Achillea erba-rotta subsp. moschata (Wulfen) I. Richardson are characterized by a consolidated traditional knowledge. Although this is not their first traditional use, they have also long been used as ingredients for skin healing and skin care. Aim of the study: The aim of this work was to characterize the two Achillea species from a chemical and biomolecular point of view in order to find a simple tool for their discrimination. At the same time, the biological activity of the extracts as inhibitors of the enzymes tyrosinase and elastase and as antimicrobial agents was evaluated. Materials and methods: The biomolecular analysis was performed on the DNA region trnL-F. The hydroalcholic (EtOH50 %) extracts were quali-quantitatively characterized by HPLC-PDA-MS/MS and tested for their inhibitory effect on the enzymes tyrosinase and elastase as well as for their antimicrobial activity. Cytotoxicity towards human fibroblasts was tested to evaluate their safety for potential applications. Results: Restriction Fragment Length Polymorphism (RFLP) analysis of the trnL-F DNA region was a useful tool for species discrimination. Both extracts are rich in polyphenols and showed moderate tyrosinase (26-5 %) and elastase (22-14 %) inhibitory activity at 17 μg/mL. They were also able to inhibit the growth of the bacteria and yeasts studied, generally exhibiting cytotoxicity to human fibroblasts at concentrations of 500 μg/mL or higher. Conclusions: The hydroalcoholic extracts from the aerial parts of A. millefolium and A. erba-rotta subsp. moschata can be considered good candidates for the cosmetic and health sectors, also supporting the traditional use of these species in the treatment of skin diseases.eng
dc.identifier.doi10.1016/j.jep.2025.120123
dc.identifier.urihttp://hdl.handle.net/10400.6/18927
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationNot Available
dc.relation2021.07634.BD
dc.relationHealth Sciences Research Centre
dc.relationCICS-UBI
dc.relationUIDB/00709/2020
dc.relationUIDP/00709/2020
dc.rights.uriN/A
dc.subjectAchillea millefolium L.
dc.subjectAchillea erba-rotta subsp. moschata (Wulfen) I.
dc.subjectRichardson
dc.subjectPhenolic compounds
dc.subjecttrnL-F DNA region
dc.subjectAnti-Tyrosinase
dc.subjectAnti-Elastase
dc.subjectAntimicrobial
dc.titleCharacterization and evaluation of Achillea erba-rotta subsp. moschata (Wulfen) I. Richardson and Achillea millefolium L. as potential ingredients for skin applicationspor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNot Available
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleCICS-UBI
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/DL 57%2F2016/DL 57%2F2016%2FCP1354%2FCT0010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/2021.07634.BD/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Programático/UIDP%2F00709%2F2020/PT
oaire.citation.titleJournal of Ethnopharmacology
oaire.fundingStreamDL 57/2016
oaire.fundingStreamPOR_CENTRO
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Programático
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameMarengo
person.familyNameCagliero
person.familyNameSgorbini
person.familyNameFusani
person.familyNameDuarte
person.familyNameLuís
person.familyNameFonseca
person.familyNameFeijó
person.familyNameSocorro
person.familyNameBertea
person.familyNameRubiolo
person.givenNameArianna
person.givenNameCecilia
person.givenNameBarbara
person.givenNameMenzio, Giulia
person.givenNamePietro
person.givenNameAna Paula
person.givenNameÂngelo Filipe Santos
person.givenNameLara R. S.
person.givenNameMariana Pombal
person.givenNameSílvia Cristina da Cruz Marques
person.givenNameCinzia Margherita
person.givenNamePatrizia
person.identifier1255684
person.identifierhttps://scholar.google.pt/citations?user=PA3L_h8AAAAJ&hl=pt-PT
person.identifier.ciencia-idBC15-D376-80FE
person.identifier.ciencia-id3D14-798B-65D3
person.identifier.ciencia-id1618-46EE-4DA4
person.identifier.ciencia-idFC1F-F519-8104
person.identifier.ciencia-idAB17-5C25-1F2C
person.identifier.orcid0000-0002-1777-2264
person.identifier.orcid0000-0003-3512-6124
person.identifier.orcid0000-0001-6848-1304
person.identifier.orcid0009-0003-6057-011X
person.identifier.orcid0000-0001-8643-8414
person.identifier.orcid0000-0003-3333-5977
person.identifier.orcid0000-0003-0712-6522
person.identifier.orcid0000-0002-8789-4048
person.identifier.orcid0000-0002-5330-5276
person.identifier.orcid0000-0001-8181-488X
person.identifier.orcid0000-0003-2919-0445
person.identifier.orcid0000-0002-6819-2614
person.identifier.ridB-5904-2009
person.identifier.scopus-author-id7102602131
person.identifier.scopus-author-id23097994600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublicationb0739fe7-51f9-4738-8ecf-983a7d4ce927
relation.isAuthorOfPublicationf44ab826-89b3-4362-ae55-dcac701c6067
relation.isAuthorOfPublicationabb0141f-9fda-426d-84da-2d771a581762
relation.isAuthorOfPublication1bfb6afa-e0f1-4800-b978-9ff4cb3948e3
relation.isAuthorOfPublication2db8a10e-eb48-46e0-ba50-d8ceb82fdf92
relation.isAuthorOfPublication971779ac-7c22-4f69-8bdd-4e0ec442ef2d
relation.isAuthorOfPublicationa2d7c872-99db-41e1-9bc9-82c2d47b4661
relation.isAuthorOfPublication57ca558a-71ce-4acd-9ea1-435284c1a2ee
relation.isAuthorOfPublicationf958a7b5-ba6c-4f97-8533-7be61bdc6e19
relation.isAuthorOfPublication1fb06949-0e6c-41a6-bb25-11885e7f0e9a
relation.isAuthorOfPublication2a7cc684-727b-44c8-a2c7-b34e28183135
relation.isAuthorOfPublication277c7f19-3424-4601-8f53-303b944043be
relation.isAuthorOfPublication.latestForDiscoveryf44ab826-89b3-4362-ae55-dcac701c6067
relation.isProjectOfPublicatione4a98845-fa46-4626-b118-1ba89fd7067f
relation.isProjectOfPublication99d13d47-e980-499b-8b91-48d1e0747b35
relation.isProjectOfPublicationc7cee677-067c-47b2-ab19-b2dd5b0fda9d
relation.isProjectOfPublicationbd9f3377-93f3-4de6-aa9d-f89c7d0d7bfc
relation.isProjectOfPublication.latestForDiscoverye4a98845-fa46-4626-b118-1ba89fd7067f

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Characterization and evaluation of Achillea erba-rotta subsp. moschata (Wulfen) I. Richardson and Achillea millefolium L. as potential ingredients for skin applications
Size:
3.64 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
4.03 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ICI - CICS | Documentos por Auto-Depósito