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CD45RA, CD8β, and IFNγ Are Potential Immune Biomarkers of Human Cognitive Function

2020Journal article Open access
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dc.contributor.authorEsgalhado, AJ
dc.contributor.authorReste-Ferreira, Débora
dc.contributor.authorAlbino, Stephanie
dc.contributor.authorSousa, Adriana
dc.contributor.authorAmaral, Ana Paula
dc.contributor.authorMartinho, António
dc.contributor.authorOliveira, Isabel Tomás
dc.contributor.authorVerde, Ignacio
dc.contributor.authorLourenço, Olga
dc.contributor.authorFonseca, Ana M
dc.contributor.authorCardoso, Elsa M.
dc.contributor.authorArosa, FA
dc.date.accessioned2021-07-05T10:11:52Z
dc.date.available2021-07-05T10:11:52Z
dc.date.issued2020
dc.description.abstractThere is increasing evidence that in humans the adaptive immunological system can influence cognitive functions of the brain. We have undertaken a comprehensive immunological analysis of lymphocyte and monocyte populations as well as of HLA molecules expression in a cohort of elderly volunteers (age range, 64-101) differing in their cognitive status. Hereby, we report on the identification of a novel signature in cognitively impaired elderly characterized by: (1) elevated percentages of CD8+ T effector-memory cells expressing high levels of the CD45RA phosphate receptor (Temra hi); (2) high percentages of CD8+ T cells expressing high levels of the CD8β chain (CD8βhi); (3) augmented production of IFNγ by in vitro activated CD4+ T cells. Noteworthy, CD3+CD8+ Temra hi and CD3+CD8βhi cells were associated with impaired cognition. Cytomegalovirus seroprevalence showed that all volunteers studied but one were CMV positive. Finally, we show that some of these phenotypic and functional features are associated with an increased frequency of the HLA-B8 serotype, which belongs to the ancestral haplotype HLA-A1, Cw7, B8, DR3, DQ2, among cognitively impaired volunteers. To our knowledge, this is the first proof in humans linking the amount of cell surface CD45RA and CD8β chain expressed by CD8+ Temra cells, and the amount of IFNγ produced by in vitro activated CD4+ T cells, with impaired cognitive function in the elderly.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3389/fimmu.2020.592656pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/11184
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationHealth Sciences Research Centre
dc.subjectCD8 Antigenspt_PT
dc.subjectCD8-Positive T-Lymphocytespt_PT
dc.subjectCognitive Dysfunctionpt_PT
dc.subjectHumanspt_PT
dc.subjectImmunophenotypingpt_PT
dc.subjectInterferon-gammapt_PT
dc.subjectLeukocyte Common Antigenspt_PT
dc.subjectLeukocytes, Mononuclearpt_PT
dc.subjectLymphocyte Activationpt_PT
dc.subjectPrevalencept_PT
dc.subjectT-Lymphocyte Subsetspt_PT
dc.subjectBiomarkerspt_PT
dc.subjectCognitionpt_PT
dc.titleCD45RA, CD8β, and IFNγ Are Potential Immune Biomarkers of Human Cognitive Functionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.citation.startPage592656pt_PT
oaire.citation.titleFrontiers in immunologypt_PT
oaire.citation.volume11pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameGabriel Esgalhado
person.familyNameReste Ferreira
person.familyNameAlbino
person.familyNameMARTINHO
person.familyNameSoeiro Tomás de Oliveira
person.familyNameVerde
person.familyNameLourenço
person.familyNamePereira de Oliveira Cardoso
person.familyNameArosa
person.givenNameAndré João
person.givenNameDébora Alexandra
person.givenNameStephanie
person.givenNameANTONIO
person.givenNameIsabel Maria
person.givenNameIgnacio
person.givenNameOlga Maria Marques
person.givenNameElsa Maria
person.givenNameFernando
person.identifierhttps://scholar.google.com/citations?user=NhbmSmEAAAAJ&hl=en
person.identifierAAL-5774-2020
person.identifier83032
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person.identifier.scopus-author-id57201150290
person.identifier.scopus-author-id55913729400
person.identifier.scopus-author-id6604045863
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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