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Nano‐in‐Micro POxylated Polyurea Dendrimers and Chitosan Dry Powder Formulations for Pulmonary Delivery

2016-08-03Journal article Restricted access
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dc.contributor.authorRestani, Rita
dc.contributor.authorSilva, A. Sofia
dc.contributor.authorPires, Rita
dc.contributor.authorCabral, Renato
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.contributor.authorCasimiro, Teresa
dc.contributor.authorBonifácio, Vasco
dc.contributor.authorRicardo, Ana Aguiar
dc.date.accessioned2018-03-21T14:18:03Z
dc.date.available2018-03-21T14:18:03Z
dc.date.issued2016-08-03
dc.description.abstractPulmonary administration offers excellent advantages over conventional drug delivery routes, including increasing therapeutics bioavailability, and avoiding long‐term safety issues. Formulations of nano‐in‐micro dry powders for lung delivery are engineered using (S)‐ibuprofen as a model drug. These biodegradable formulations comprise nanoparticles of drug‐loaded POxylated polyurea dendrimers coated with chitosan using supercritical‐fluid‐assisted spray drying. The formulations are characterized in terms of morphology, particle‐size distribution, in vitro aerodynamic particle pulmonary distribution, and glutathione‐S‐transferase assay. It is demonstrated that ibuprofen‐loaded nanoparticles can be successfully incorporated into microspheres with adequate aerodynamic properties, mass median aerodynamic diameter (1.86–3.83 μm), and fine particle fraction (28%–45%), for deposition into the deep lung. The (S)‐ibuprofen dry powder formulations show enhanced solubility, high swelling behavior and a sustained drug release at physiologic pH. Also, POxylated polyureas decrease the (S)‐ibuprofen toxic effect on cancer cellular growth. The 3‐(4,5‐dimethylthiazol‐2‐yl)‐5‐(3‐carboxymethoxyphenyl)‐2‐(4‐sulfophenyl)‐2H‐tetrazolium (MTS) assays show no significant cytotoxicity on the metabolic activity of human lung adenocarcinoma ephithelial (A549) cell line for the lowest concentration (1 × 10−3 m), even for longer periods of contact with the cells (up to 120 h), and in the normal human dermal fibroblasts cell line the toxic effect is also reduced.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRestani, R. B., Silva, A. S., Pires, R. F., Cabral, R., Correia, I. J., Casimiro, T., Bonifácio, V. D. B. e Aguiar‐Ricardo, A. (2016) “Nano‐in‐Micro POxylated Polyurea Dendrimers and Chitosan Dry Powder Formulations for Pulmonary Delivery.” Particle & Particle Systems Characterization, Vol.33 (11), pp.851-858pt_PT
dc.identifier.doi10.1002/ppsc.201600123pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4686
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationSmart porous particles for pulmonary drug and vaccine delivery
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/abs/10.1002/ppsc.201600123pt_PT
dc.subjectIbuprofenpt_PT
dc.subjectPolyureapt_PT
dc.subjectDendrimerspt_PT
dc.subjectChitosanpt_PT
dc.titleNano‐in‐Micro POxylated Polyurea Dendrimers and Chitosan Dry Powder Formulations for Pulmonary Deliverypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleSmart porous particles for pulmonary drug and vaccine delivery
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F50006%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEQU-EQU%2F116097%2F2009/PT
oaire.citation.endPage858pt_PT
oaire.citation.startPage851pt_PT
oaire.citation.titleParticle & Particle Systems Characterizationpt_PT
oaire.citation.volume33pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
person.familyNameMatias da Silva
person.familyNameCabral
person.familyNameJoaquim Sobreira Correia
person.familyNameCasimiro
person.familyNameBonifácio
person.familyNameAguiar-Ricardo
person.givenNameAna Sofia
person.givenNameRenato
person.givenNameIlídio
person.givenNameTeresa
person.givenNameVasco Daniel Bigas
person.givenNameAna
person.identifierUMbJ1KMAAAAJ
person.identifierbit.ly/google_scholar_bonifacio
person.identifier239073
person.identifier.ciencia-id7A1A-FEC8-7940
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-idC319-27F6-1C6B
person.identifier.ciencia-idAE14-EB30-86A6
person.identifier.ciencia-id2C1A-9947-19BA
person.identifier.orcid0000-0002-5388-1732
person.identifier.orcid0000-0003-0762-5890
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0001-9405-6221
person.identifier.orcid0000-0003-2349-8473
person.identifier.orcid0000-0002-2193-1440
person.identifier.ridC-3286-2011
person.identifier.scopus-author-id57195299500
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id6602194100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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