Publication
17 Beta-Estradiol and progesterone inhibit L-type Ca2+ current of rat aorta smooth muscle cells
| dc.contributor.author | Verde, Ignacio | |
| dc.contributor.author | Cairrão, Elisa | |
| dc.contributor.author | Carvas, João | |
| dc.contributor.author | Silva, António José Santos | |
| dc.contributor.author | Alvarez, Ezequiel | pt |
| dc.date.accessioned | 2010-04-28T10:07:29Z | |
| dc.date.available | 2010-04-28T10:07:29Z | |
| dc.date.issued | 2006 | |
| dc.description.abstract | Sex hormones like 17ß-estradiol (ßES) and progesterone have shown rapid non-genomic vasodilator effects, which could be involved in the protection of cardiovascular system. However, the precise mechanism by which this effect occurs has not been elucidated yet, even if Ca2+ influx inhibition seems to be implicated. The aim of this study was to study the influence of ßES and progesterone on the L-type Ca2+ current measured by whole cell voltage-clamp in A7r5 cells. Voltage-operated Ca2+ currents were elicited by square-step voltage pulses and pharmacologically characterized as L-type currents by (-)-Bay K8644 (BAY) and nifedipine. Both ßES and progesterone (1-100 µM), rapidly and reversibly inhibited, in a concentration dependent manner, either non-stimulated or BAY-stimulated Ca2+ currents registered in A7r5 cells. These results suggest that ßES and progesterone inhibit L-type voltage-operated Ca2+ channels through a non-genomic pathway. Consequently, these hormones inhibit the Ca2+ entry into smooth muscle cells from rat aorta, an effect that can contribute for the protection of the cardiovascular system. | |
| dc.identifier.uri | http://hdl.handle.net/10400.6/621 | |
| dc.language | eng | |
| dc.title | 17 Beta-Estradiol and progesterone inhibit L-type Ca2+ current of rat aorta smooth muscle cells | pt |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 24:241-55 | pt |
| oaire.citation.title | Portugaliae Electrochimica Acta | pt |
| person.familyName | Verde | |
| person.familyName | Cairrao Rodrigues Oliveira | |
| person.familyName | Carvas | |
| person.familyName | Santos-Silva AJ | |
| person.givenName | Ignacio | |
| person.givenName | Maria Elisa | |
| person.givenName | João | |
| person.givenName | António José dos Santos Silva | |
| person.identifier | AAB-1164-2020 | |
| person.identifier.ciencia-id | D012-1D7C-791A | |
| person.identifier.ciencia-id | 0611-71B8-191E | |
| person.identifier.ciencia-id | 6A17-99F5-597C | |
| person.identifier.orcid | 0000-0003-3492-5725 | |
| person.identifier.orcid | 0000-0002-4823-5701 | |
| person.identifier.orcid | 0000-0002-0929-2180 | |
| person.identifier.orcid | 0000-0002-8200-1052 | |
| person.identifier.rid | M-3991-2013 | |
| person.identifier.scopus-author-id | 55913729400 | |
| person.identifier.scopus-author-id | Scopus Author ID: 23476537500 | |
| rcaap.rights | openAccess | |
| rcaap.type | article | pt |
| relation.isAuthorOfPublication | bfb58284-b817-4267-9628-8fa150aa681c | |
| relation.isAuthorOfPublication | 2718c108-c03e-44a3-98a7-b05366e0fe61 | |
| relation.isAuthorOfPublication | e398e6d7-28d6-4428-9486-8fa933214762 | |
| relation.isAuthorOfPublication | 211cd7f0-41c8-4799-874d-a94f3f0385cd | |
| relation.isAuthorOfPublication.latestForDiscovery | 211cd7f0-41c8-4799-874d-a94f3f0385cd |
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