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Controlled release gelatin hydrogels and lyophilisates with potential application as ocular inserts

2007-10-08Journal article Restricted access
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dc.contributor.authorNatu, Mădălina
dc.contributor.authorSardinha, José
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.contributor.authorGil, Maria
dc.date.accessioned2018-03-15T15:41:39Z
dc.date.available2018-03-15T15:41:39Z
dc.date.issued2007-10-08
dc.description.abstractHydrogels and lyophilisates were obtained by chemical crosslinking of gelatin using N-hydroxysuccinimide and N, N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride. The systems were characterized with respect to the degree of crosslinking, morphology, water uptake, in vitro drug release and biocompatibility studies. Pilocarpine hydrochloride, a drug for the treatment of glaucoma, was loaded by soaking in an aqueous solution containing the drug. In vitro, the released drug percentage varied between 29.2% and 99.2% in 8 h of study. The release data were fitted to the Korsmeyer–Peppas equation to calculate the release exponent, which indicated anomalous transport for the release of pilocarpine. The corneal endothelial cell culture tests indicated that the prepared biomaterials are not cytotoxic.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNatu, M.V., Sardinha, J.P., Correia, I. J. e Gil, M.H. (2007) “Controlled Release Gelatin Hydrogels and Lyophilisates with Potential Application as Ocular Inserts”, Biomedical Materials, Vol. 2(4), pp. 241-249pt_PT
dc.identifier.doi10.1088/1748-6041/2/4/006pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4621
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherIOPSCIENCEpt_PT
dc.relation.publisherversionhttp://iopscience.iop.org/article/10.1088/1748-6041/2/4/006/metapt_PT
dc.subjectHydrogelpt_PT
dc.subjectGelatinpt_PT
dc.titleControlled release gelatin hydrogels and lyophilisates with potential application as ocular insertspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage249pt_PT
oaire.citation.startPage241pt_PT
oaire.citation.titleBIOMEDICAL MATERIALSpt_PT
oaire.citation.volume2pt_PT
person.familyNameSardinha
person.familyNameJoaquim Sobreira Correia
person.familyNameGil
person.givenNameJose
person.givenNameIlídio
person.givenNameMaria Helena
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-idA31F-0D77-B9D0
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id0E10-A6F7-901B
person.identifier.orcid0000-0001-6877-6102
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0003-0657-7751
person.identifier.scopus-author-id6507420537
person.identifier.scopus-author-id7003557499
rcaap.embargofctCopyright cedido à editora no momento da publicação.pt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationc050910c-b631-41af-9aca-e57242177e21
relation.isAuthorOfPublicationf2c3e779-34a2-4309-950a-80687664c6ad
relation.isAuthorOfPublication676a8017-743a-4f22-93be-4915428f318d
relation.isAuthorOfPublication.latestForDiscoveryc050910c-b631-41af-9aca-e57242177e21

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