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Chitosan/arginine–chitosan polymer blends for assembly of nanofibrous membranes for wound regeneration

2015-05-12Journal article Restricted access
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dc.contributor.authorAntunes, Bernardo Paiva
dc.contributor.authorMoreira, André
dc.contributor.authorGaspar, Vítor Manuel Abreu
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.date.accessioned2018-03-21T09:14:56Z
dc.date.available2018-03-21T09:14:56Z
dc.date.issued2015-05-12
dc.description.abstractFrequently, skin is subjected to damaging events, such as deep cuts, burns or ulcers, which may compromise the integrity of this organ. To overcome such lesions, different strategies have been employed. Among them, wound dressings aimed to re-establish skin native properties and decreased patient pain have been pursued for a long time. Herein, an electrospun membrane comprised by deacetylated/arginine modified chitosan (CH-A) was produced to be used as a wound dressing. The obtained results showed that the membrane has a highly hydrophilic and porous three-dimensional nanofibrous network similar to that found in human native extracellular matrix. In vitro data indicate that human fibroblasts adhere and proliferate in contact with membranes, thus corroborating their biocompatibility. This nanofiber-based biomaterial also demonstrated bactericidal activity for two bacterial strains. In vivo application of CH-A nanofibers in full thickness wounds resulted in an improved tissue regeneration and faster wound closure, when compared to non-modified membranes. Such findings support the suitability of using this membrane as a wound dressing in a near future.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAntunes, B.P., Moreira, A.F., Gaspar, V.M. e Correia I.J. (2015) "Chitosan/Arginine-Chitosan polymer blends for assembly of nanofibrous membranes for wound regeneration", Carbohydrate Polymers, Vol. 130, pp.104-112pt_PT
dc.identifier.doi10.1016/j.carbpol.2015.04.072pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4672
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationStrategic Project - UI 709 - 2011-2012
dc.relation2014 - Strategic Project
dc.relationBIOSYNTHESIS AND PURIFICATION OF MINICIRCLE DNA FOR APPLICATION IN DIABETES CELL-SPECIFIC GENE THERAPY
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0144861715003999pt_PT
dc.subjectAntimicrobial Activitypt_PT
dc.subjectWound healingpt_PT
dc.subjectElectrospinningpt_PT
dc.subjectChitosanpt_PT
dc.subjectArgininept_PT
dc.titleChitosan/arginine–chitosan polymer blends for assembly of nanofibrous membranes for wound regenerationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 709 - 2011-2012
oaire.awardTitle2014 - Strategic Project
oaire.awardTitleBIOSYNTHESIS AND PURIFICATION OF MINICIRCLE DNA FOR APPLICATION IN DIABETES CELL-SPECIFIC GENE THERAPY
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FSAU%2FUI0709%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FSAU%2FUI0709%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBD%2F80402%2F2011/PT
oaire.citation.endPage112pt_PT
oaire.citation.startPage104pt_PT
oaire.citation.titleCarbohydrate Polymerspt_PT
oaire.citation.volume130pt_PT
oaire.fundingStream6820 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamFARH
person.familyNameMoreira
person.familyNameGaspar
person.familyNameJoaquim Sobreira Correia
person.givenNameAndré Ferreira
person.givenNameVítor
person.givenNameIlídio
person.identifier1161643
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-id6F16-3640-73E3
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0002-0372-2493
person.identifier.orcid0000-0003-1613-9675
person.identifier.ridB-1602-2017
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id36968590900
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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