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Oxidative Stress, DNA, Cell Cycle/Cell Cycle Associated Proteins and Multidrug Resistance Proteins: Targets of Human Amniotic Membrane in Hepatocellular Carcinoma

2016-10Journal article Restricted access
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dc.contributor.authorMamede, Ana Catarina Manjolinha
dc.contributor.authorGuerra, S
dc.contributor.authorLaranjo, Marta
dc.contributor.authorSantos, K
dc.contributor.authorCarvalho, Maria J
dc.contributor.authorCarvalheiro, Tiago
dc.contributor.authorMoura, P
dc.contributor.authorPaiva, A
dc.contributor.authorAbrantes, Ana M
dc.contributor.authorBaptista, Cláudio
dc.contributor.authorBotelho, M F
dc.date.accessioned2019-12-20T12:12:26Z
dc.date.available2019-12-20T12:12:26Z
dc.date.issued2016-10
dc.description.abstractThe anticancer effects of human amniotic membrane (hAM) have been studied over the last decade. However, the action mechanisms responsible for these effects are not fully understood until now. Previously results reported by our team proved that hAM is able to induce cytotoxicity and cell death in hepatocellular carcinoma (HCC), a worldwide high incident and mortal cancer. Therefore, this experimental study aimed to investigate the cellular targets of hAM protein extracts (hAMPE) in HCC through in vitro studies. Our results showed that hAMPE is able to modify oxidative stress environment in all HCC cell lines, as well as its cell cycle. hAMPE differently targets deoxyribonucleic acid (DNA), P21, P53, β-catenin and multidrug resistance (MDR) proteins in HCC cell lines. In conclusion, hAMPE has several targets in HCC, being clear that the success of this treatment depends of a personalized therapy based on the biological and genetic characteristics of the tumor.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s12253-016-0053-xpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/8001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectHuman amniotic membranept_PT
dc.subjectHepatocellular carcinomapt_PT
dc.subjectProtein extractspt_PT
dc.subjecthAMPEpt_PT
dc.subjectOxidative stresspt_PT
dc.subjectCell cyclept_PT
dc.titleOxidative Stress, DNA, Cell Cycle/Cell Cycle Associated Proteins and Multidrug Resistance Proteins: Targets of Human Amniotic Membrane in Hepatocellular Carcinomapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PEst-C%2FSAU%2FUI3282%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FNEU%2F04539%2F2013/PT
oaire.citation.endPage697pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage689pt_PT
oaire.citation.titlePathology and Oncology Researchpt_PT
oaire.citation.volume22pt_PT
oaire.fundingStreamCOMPETE
oaire.fundingStream5876
person.familyNameLaranjo
person.familyNameCarvalho
person.familyNameCarvalheiro
person.familyNameAbrantes
person.familyNameMaia Baptista
person.familyNameBotelho
person.givenNameMarta
person.givenNameMaria J
person.givenNameTiago
person.givenNameAna M
person.givenNameCláudio Jorge
person.givenNameMaria Filomena
person.identifierI-6040-2012
person.identifier2085222
person.identifier944645
person.identifierR-000-10V
person.identifierhttps://scholar.google.pt/citations?user=hFKOd_QAAAAJ&hl=pt-PT&oi=ao
person.identifierR-000-BFD
person.identifier.ciencia-id861A-EEAC-70E0
person.identifier.ciencia-id2B1C-C120-B274
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person.identifier.ciencia-id7818-2E25-9410
person.identifier.ciencia-id5115-FCBD-A31F
person.identifier.ciencia-idD716-3387-EAC1
person.identifier.orcid0000-0002-3900-5592
person.identifier.orcid0000-0001-6819-927X
person.identifier.orcid0000-0002-3187-2288
person.identifier.orcid0000-0003-4185-7871
person.identifier.orcid0000-0002-5658-5445
person.identifier.orcid0000-0001-7202-1650
person.identifier.ridG-6913-2018
person.identifier.ridG-1860-2011
person.identifier.scopus-author-id7801545833
person.identifier.scopus-author-id55440132400
person.identifier.scopus-author-id26029747600
person.identifier.scopus-author-id23097426600
person.identifier.scopus-author-id7005751167
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicação.pt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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