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Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites

2019-01-25Journal article Open access
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dc.contributor.authorVassal, Mariana
dc.contributor.authorNunes-Pereira, João
dc.contributor.authorMiguel, Sónia
dc.contributor.authorCorreia, Ilidio
dc.contributor.authorSilva, Abilio
dc.date.accessioned2019-03-07T17:19:31Z
dc.date.available2022-03-08T01:30:16Z
dc.date.issued2019-01-25
dc.description.abstractThe biofunctionalization of metal implants with bioactive ceramics arises as an appealing strategy for promoting their osseointegration, without impairing implants’ good mechanical resistance. In this work, biocomposites of hydroxyapatite - CaZrO3 were obtained by rate controlled sintering and their microstructure, mechanical properties, biological as well as the effect of stoichiometric calcium zirconate dopant on the decomposition of HA were analysed. The results obtained showed that the addition of CaZrO3 stabilizes the hydroxyapatite at least up to 1300 °C and inhibits the appearance of the α- and β-TCP phases. Moreover, the mechanical properties of the hydroxyapatite were improved with 10 wt% of CaZrO3, despite the increase of porosity. The in vitro assays demonstrated that the biocomposites were biocompatible, since they favoured human osteoblast cells adhesion and proliferation. All the data obtained emphasize the potential of these biocomposites for the aimed biomedical application.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.ceramint.2019.01.122pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/6897
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
dc.subjectHydroxyapatitept_PT
dc.subjectCalcium zirconatept_PT
dc.subjectCeramic biocompositespt_PT
dc.subjectMechanical propertiespt_PT
dc.subjectBioactivitypt_PT
dc.titleMicrostructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocompositespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FEMS%2F00151%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109563%2F2015/PT
oaire.citation.conferencePlaceHolandapt_PT
oaire.citation.titleCeramics Internationalpt_PT
oaire.fundingStream5876
oaire.fundingStreamPOR_CENTRO
person.familyNameVassal
person.familyNameNunes-Pereira
person.familyNamePereira Miguel
person.familyNameCorreia
person.familyNameSilva
person.givenNameMariana
person.givenNameJoão
person.givenNameSónia Alexandra
person.givenNameIlídio Joaquim Sobreira
person.givenNameAbilio
person.identifierGX0L2QAAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-idD411-E99C-E2C1
person.identifier.ciencia-id6D16-6F7E-64F0
person.identifier.ciencia-id1A13-ABC0-C32C
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-idD314-9C94-0B0F
person.identifier.orcid0000-0002-6024-8716
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0002-2100-7223
person.identifier.ridAAD-6349-2020
person.identifier.ridO-1474-2013
person.identifier.scopus-author-id57200519831
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id8540933900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctOs direitos de autor foram cedidos à editora Elsevierpt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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