Repository logo
 
Publication

Cyclic GMP regulation of the L-type Ca2+ channel current in human atrial myocytes

2001Journal article Open access
Simple item page
dc.contributor.authorVerde, Ignacio
dc.contributor.authorVandecasteele, Grégoire
dc.contributor.authorRucker-Martin, C.pt
dc.contributor.authorDonzeau-Gouge, P.pt
dc.contributor.authorFischmeister, Rodolphept
dc.date.accessioned2010-04-28T10:06:46Z
dc.date.available2010-04-28T10:06:46Z
dc.date.issued2001
dc.description.abstractThe cardiac L-type Ca2+ channel current (ICa) is an important determinant of myocardial contractility. Its regulation by neurotransmitters, hormones, and paracrine factors contributes to the control of cardiac output to meet the demands of the body. A large number of these extracellular first messengers, acting on specific membrane receptors in cardiac myocytes, regulate the activity of adenylyl cyclase which in turn controls the intracellular concentration of cAMP, the activity of the cAMPdependent protein kinase (PKA), and the degree of phosphorylation and stimulation of L-type Ca2+ channels (Hartzell, 1988; McDonald et al. 1994; Hove-Madsen et al. 1996; Striessnig, 1999). A typical example of such regulation is the control of heart function by the sympathetic and parasympathetic nervous systems, which act via adrenoceptors and muscarinic receptors (Brodde & Michel, 1999). In addition to the cAMP cascade, other factors regulate heart function by acting primarily on the cGMP cascade; these include atrial and brain natriuretic peptides (de Bold et al.1996) and nitric oxide (NO) (Paulus & Shah, 1999; Shah & MacCarthy, 2000).
dc.identifier.urihttp://hdl.handle.net/10400.6/547
dc.language.isoengpt
dc.titleCyclic GMP regulation of the L-type Ca2+ channel current in human atrial myocytespt
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue533:329-40pt
oaire.citation.titleJournal of Physiology-Londonpt
person.familyNameVerde
person.familyNameVandecasteele
person.givenNameIgnacio
person.givenNameGrégoire
person.identifier.ciencia-idD012-1D7C-791A
person.identifier.orcid0000-0003-3492-5725
person.identifier.orcid0000-0002-4046-4171
person.identifier.ridM-3991-2013
person.identifier.scopus-author-id55913729400
rcaap.rightsopenAccesspt
rcaap.typearticlept
relation.isAuthorOfPublicationbfb58284-b817-4267-9628-8fa150aa681c
relation.isAuthorOfPublicationd11a75df-74f0-4cb6-a49a-0ee646ffc342
relation.isAuthorOfPublication.latestForDiscoveryd11a75df-74f0-4cb6-a49a-0ee646ffc342

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
t02101pdf.pdf
Size:
323.07 KB
Format:
Adobe Portable Document Format
Download

Collections

FCS - DCM | Documentos por Auto-Depósito