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Histopathological and in vivo evidence of regucalcin as a protective molecule in mammary gland carcinogenesis

2015-01-15Journal article Restricted access
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dc.contributor.authorMarques, Ricardo
dc.contributor.authorVaz, Cátia
dc.contributor.authorBaptista, Cláudio
dc.contributor.authorGomes, Madalena
dc.contributor.authorGama, Adelina
dc.contributor.authorAlves, Gilberto
dc.contributor.authorSantos, Cecilia
dc.contributor.authorSchmitt, Fernando
dc.contributor.authorSocorro, Sílvia
dc.date.accessioned2019-12-04T17:00:56Z
dc.date.available2019-12-04T17:00:56Z
dc.date.issued2015-01-15
dc.description.abstractRegucalcin (RGN) is a calcium-binding protein, which has been shown to be underexpressed in cancer cases. This study aimed to determine the association of RGN expression with clinicopathological parameters of human breast cancer. In addition, the role of RGN in malignancy of mammary gland using transgenic rats overexpressing the protein (Tg-RGN) was investigated. Wild-type (Wt) and Tg-RGN rats were treated with 7,12-dimethylbenz[α]anthracene (DMBA). Carcinogen-induced tumors were histologically classified and the Ki67 proliferation index was estimated. Immunohistochemistry analysis showed that RGN immunoreactivity was negatively correlated with the histological grade of breast infiltrating ductal carcinoma suggesting that progression of breast cancer is associated with loss of RGN. Tg-RGN rats displayed lower incidence of carcinogen-induced mammary gland tumors, as well as lower incidence of invasive forms. Moreover, higher proliferation was observed in non-invasive tumors of Wt animals comparatively with Tg-RGN. Overexpression of RGN was associated with diminished expression of cell-cycle inhibitors and increased expression of apoptosis inducers. Augmented activity of apoptosis effector caspase-3 was found in the mammary gland of Tg-RGN. RGN overexpression protected from carcinogen-induced mammary gland tumor development and was linked with reduced proliferation and increased apoptosis. These findings indicated the protective role of RGN in the carcinogenesis of mammary gland.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.yexcr.2014.08.007pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/7662
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationStrategic Project - UI 709 - 2011-2012
dc.relation2014 - Strategic Project
dc.relationROLE OF REGUCALCIN IN BREAST CELLS PROLIFERATION AND TUMOR DEVELOPMENT
dc.subjectApoptosispt_PT
dc.subjectBreast cancerpt_PT
dc.subjectCarcinogenpt_PT
dc.subjectDMBApt_PT
dc.subjectMammary glandpt_PT
dc.subjectRegucalcinpt_PT
dc.titleHistopathological and in vivo evidence of regucalcin as a protective molecule in mammary gland carcinogenesispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 709 - 2011-2012
oaire.awardTitle2014 - Strategic Project
oaire.awardTitleROLE OF REGUCALCIN IN BREAST CELLS PROLIFERATION AND TUMOR DEVELOPMENT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FSAU%2FUI0709%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FSAU%2FUI0709%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F70316%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F66875%2F2009/PT
oaire.citation.endPage335pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage325pt_PT
oaire.citation.titleExperimental Cell Researchpt_PT
oaire.citation.volume330pt_PT
oaire.fundingStream6820 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamSFRH
person.familyNameVaz
person.familyNameMaia Baptista
person.familyNameGama
person.familyNameAlves
person.familyNameSANTOS
person.familyNameSchmitt
person.familyNameSocorro
person.givenNameCátia
person.givenNameCláudio Jorge
person.givenNameAdelina
person.givenNameGilberto
person.givenNameCecília Reis Alves
person.givenNameFernando
person.givenNameSílvia Cristina da Cruz Marques
person.identifierhttps://scholar.google.pt/citations?user=hFKOd_QAAAAJ&hl=pt-PT&oi=ao
person.identifierhttps://scholar.google.pt/citations?user=PA3L_h8AAAAJ&hl=pt-PT
person.identifier.ciencia-id1C1D-F91F-D937
person.identifier.ciencia-id5115-FCBD-A31F
person.identifier.ciencia-id4010-DBC5-0DA5
person.identifier.ciencia-id761A-7ED2-D68F
person.identifier.ciencia-idAB17-5C25-1F2C
person.identifier.orcid0000-0002-7720-4234
person.identifier.orcid0000-0002-5658-5445
person.identifier.orcid0000-0002-6655-3076
person.identifier.orcid0000-0002-4213-0714
person.identifier.orcid0000-0001-6074-7825
person.identifier.orcid0000-0003-1006-6946
person.identifier.orcid0000-0001-8181-488X
person.identifier.ridK-2990-2013
person.identifier.scopus-author-id23097426600
person.identifier.scopus-author-id7004545690
person.identifier.scopus-author-id55663631700
person.identifier.scopus-author-id7202545664
person.identifier.scopus-author-id23097994600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicação.pt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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