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Cannabis and Its Secondary Metabolites: Their Use as Therapeutic Drugs, Toxicological Aspects, and Analytical Determination

2019Journal article Open access
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dc.contributor.authorGonçalves, Joana
dc.contributor.authorRosado, Tiago
dc.contributor.authorSoares, Sofia
dc.contributor.authorSimão, Ana
dc.contributor.authorCaramelo, Débora Almeida
dc.contributor.authorLuís, Ângelo
dc.contributor.authorFernández, Nicolás
dc.contributor.authorBarroso, Mário
dc.contributor.authorGallardo, Eugenia
dc.contributor.authorDuarte, Ana Paula
dc.date.accessioned2020-01-28T15:17:36Z
dc.date.available2020-01-28T15:17:36Z
dc.date.issued2019
dc.description.abstractAlthough the medicinal properties of Cannabis species have been known for centuries, the interest on its main active secondary metabolites as therapeutic alternatives for several pathologies has grown in recent years. This potential use has been a revolution worldwide concerning public health, production, use and sale of cannabis, and has led inclusively to legislation changes in some countries. The scientific advances and concerns of the scientific community have allowed a better understanding of cannabis derivatives as pharmacological options in several conditions, such as appetite stimulation, pain treatment, skin pathologies, anticonvulsant therapy, neurodegenerative diseases, and infectious diseases. However, there is some controversy regarding the legal and ethical implications of their use and routes of administration, also concerning the adverse health consequences and deaths attributed to marijuana consumption, and these represent some of the complexities associated with the use of these compounds as therapeutic drugs. This review comprehends the main secondary metabolites of Cannabis, approaching their therapeutic potential and applications, as well as their potential risks, in order to differentiate the consumption as recreational drugs. There will be also a focus on the analytical methodologies for their analysis, in order to aid health professionals and toxicologists in cases where these compounds are present.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/medicines6010031pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/8812
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectAnalytical determinationpt_PT
dc.subjectCannabinoidspt_PT
dc.subjectCannabispt_PT
dc.subjectLegalizationpt_PT
dc.subjectTherapeuticspt_PT
dc.subjectToxicologypt_PT
dc.titleCannabis and Its Secondary Metabolites: Their Use as Therapeutic Drugs, Toxicological Aspects, and Analytical Determinationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.citation.issue1pt_PT
oaire.citation.startPage31pt_PT
oaire.citation.titleMedicinespt_PT
oaire.citation.volume6pt_PT
oaire.fundingStream5876
person.familyNameGonçalves
person.familyNameRosado
person.familyNameSoares
person.familyNameCaramelo
person.familyNameSantos Luís
person.familyNameFernández
person.familyNameBarroso
person.familyNameGallardo
person.familyNameDuarte
person.givenNameJoana
person.givenNameTiago
person.givenNameSofia
person.givenNameDébora
person.givenNameÂngelo Filipe
person.givenNameNicolás
person.givenNameMário
person.givenNameEugenia
person.givenNameAna Paula
person.identifier2664004
person.identifier908303
person.identifier1255684
person.identifier.ciencia-idC21B-DCC7-1C44
person.identifier.ciencia-id0214-8794-861B
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person.identifier.ciencia-id5110-F476-ECCC
person.identifier.ciencia-idF617-5CA5-EF61
person.identifier.ciencia-idBC15-D376-80FE
person.identifier.orcid0000-0001-8702-415X
person.identifier.orcid0000-0003-0469-2895
person.identifier.orcid0000-0002-3524-5791
person.identifier.orcid0000-0002-6135-9645
person.identifier.orcid0000-0003-0712-6522
person.identifier.orcid0000-0002-0980-3921
person.identifier.orcid0000-0001-8848-2734
person.identifier.orcid0000-0002-1802-8998
person.identifier.orcid0000-0003-3333-5977
person.identifier.ridM-7410-2017
person.identifier.ridB-5904-2009
person.identifier.scopus-author-id57191891820
person.identifier.scopus-author-id57204097945
person.identifier.scopus-author-id35329243100
person.identifier.scopus-author-id24721485300
person.identifier.scopus-author-id7102602131
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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