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Multifunctional targeted solid lipid nanoparticles for combined photothermal therapy and chemotherapy of breast cancer

2023-04-28Journal article Open access
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dc.contributor.authorGranja, Andreia
dc.contributor.authorLima-Sousa, Rita
dc.contributor.authorAlves, Cátia
dc.contributor.authorde Melo-Diogo, Duarte
dc.contributor.authorNunes, Cláudia
dc.contributor.authorSousa, Célia T.
dc.contributor.authorCorreia, I.J.
dc.contributor.authorReis, Salette
dc.date.accessioned2023-06-12T09:13:06Z
dc.date.available2023-06-12T09:13:06Z
dc.date.issued2023-04-28
dc.description.abstractPhotothermal therapy has emerged as a new promising strategy for the management of cancer, either alone or combined with other therapeutics, such as chemotherapy. The use of nanoparticles for multimodal therapy can improve treatment performance and reduce drug doses and associated side effects. Here we propose the development of a novel multifunctional nanosystem based on solid lipid nanoparticles co-loaded with gold nanorods and mitoxantrone and functionalized with folic acid for dual photothermal therapy and chemotherapy of breast cancer. Nanoparticles were produced using an economically affordable method and presented suitable physicochemical properties for tumor passive accumulation. Upon Near-Infrared irradiation (808 nm, 1.7 W cm -2, 5 min), nanoparticles could effectively mediate a temperature increase of >20 ◦C. Moreover, exposure to light resulted in an enhanced release of Mitoxantrone. Furthermore, nanoparticles were non-hemolytic and well tolerated by healthy cells even at high concentrations. The active targeting strategy was found to be successful, as shown by the greater accumulation of the functionalized nanoparticles in MCF-7 cells. Finally, the combined effects of chemotherapy, light-induced drug release and photothermal therapy significantly enhanced breast cancer cell death. Overall, these results demonstrate that the developed lipid nanosystem is an efficient vehicle for breast cancer multimodal therapy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.bioadv.2023.213443pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/13353
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationSilk Sericin as an industrial wastewater with valuable biomedical potential
dc.relationBreast cancer synergistic therapy based on targeted lipid nanoparticles
dc.relationInjectable in situ forming graphene-based hydrogels for double immune checkpoint inhibitor photothermal therapy
dc.relationDevelopment of a responsive multi-layer microneedle patch for the sequential PTT/PDT and immunotherapy of invasive breast cancer
dc.relationShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectBreast cancerpt_PT
dc.subjectFolic acidpt_PT
dc.subjectGold nanorodspt_PT
dc.subjectMitoxantronept_PT
dc.subjectMultimodal therapypt_PT
dc.subjectSolid lipid nanoparticlespt_PT
dc.titleMultifunctional targeted solid lipid nanoparticles for combined photothermal therapy and chemotherapy of breast cancerpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleSilk Sericin as an industrial wastewater with valuable biomedical potential
oaire.awardTitleBreast cancer synergistic therapy based on targeted lipid nanoparticles
oaire.awardTitleInjectable in situ forming graphene-based hydrogels for double immune checkpoint inhibitor photothermal therapy
oaire.awardTitleDevelopment of a responsive multi-layer microneedle patch for the sequential PTT/PDT and immunotherapy of invasive breast cancer
oaire.awardTitleShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBTA-BTA%2F0696%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F130147%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F144922%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F145386%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND4ed/2021.00590.CEECIND%2FCP1661%2FCT0001/PT
oaire.citation.conferencePlaceHolandapt_PT
oaire.citation.startPage213443pt_PT
oaire.citation.titleBiomaterials Advancespt_PT
oaire.citation.volume151pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStreamPOR_NORTE
oaire.fundingStreamPOR_CENTRO
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person.familyNameAlmeida Granja
person.familyNameSousa
person.familyNameAlves
person.familyNameMiguel de Melo Diogo
person.familyNameLacerda Nunes
person.familyNamePeixoto de Sousa
person.familyNameJoaquim Sobreira Correia
person.familyNameReis
person.givenNameAndreia
person.givenNameAna Rita Lima
person.givenNameCátia Gomes
person.givenNameDuarte
person.givenNameCláudia Daniela
person.givenNameCélia Maria
person.givenNameIlídio
person.givenNameSalette
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person.identifier.orcid0000-0002-1502-3710
person.identifier.orcid0000-0001-6876-9906
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0002-0736-2835
person.identifier.ridB-1125-2019
person.identifier.scopus-author-id57201215315
person.identifier.scopus-author-id57201213407
person.identifier.scopus-author-id56266511300
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project.funder.nameFundação para a Ciência e a Tecnologia
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rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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