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Impact of exercise training on cardiotoxicity and cardiac health outcomes in women with breast cancer anthracycline chemotherapy: a study protocol for a randomized controlled trial

2019Journal article Open access
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dc.contributor.authorAntunes, Pedro Miguel da Silva
dc.contributor.authorEsteves, Dulce
dc.contributor.authorNunes, Célia
dc.contributor.authorSampaio, Francisco
dc.contributor.authorAscensão, António
dc.contributor.authorVilela, Eduardo
dc.contributor.authorTeixeira, Madalena
dc.contributor.authorAmarelo, Anabela Leal
dc.contributor.authorJoaquim, Ana
dc.date.accessioned2020-01-23T10:23:19Z
dc.date.available2020-01-23T10:23:19Z
dc.date.issued2019
dc.description.abstractAnthracyclines are chemotherapeutic agents frequently used in breast cancer (BC) treatment. Although it improves disease-free and overall survival, the use of anthracyclines is associated with a cumulative risk of cardiac toxicity. Preventive strategies to optimize cardiac health are needed and exercise is proposed as a potential non-pharmacological approach for counteracting anthracycline-related cardiotoxicity (ARC). Most of the data on the effects of exercise to reduce ACT are from animal studies, with only a few studies in a limited number of patients indicating beneficial effects. To better understand the effectiveness of exercise in the mitigation of ARC, clinical, real-world trials claim require a larger sample size and more accurate and valuable clinical biomarkers. In this study, we intend to include a large sample and investigate cardiac function through serial measures of biomarkers and imaging techniques.pt_PT
dc.description.sponsorshipBanco Santander (BID/ICI-FCSH/SANTANDER UNIVERSIDADES-UBI/2017)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAntunes P., Esteves D., Nunes C., Sampaio F., Ascensão A., Vilela A., Teixeira M., Amarelo L. A, Joaquim A. (2019) Impact of physical exercise on cardiotoxicity and cardiac health outcomes in women with breast cancer undergoing anthracycline-containing chemotherapy: a study protocol for a randomized controlled trial. Trials 20(1):433. doi: 10.1186/s13063-019-3499-9.pt_PT
dc.identifier.doi10.1186/s13063-019-3499-9pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/8648
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBreast cancerpt_PT
dc.subjectCardiotoxicitypt_PT
dc.subjectCardiac healthcarept_PT
dc.subjectSupervised exercisept_PT
dc.subjectSupportive cancer carept_PT
dc.titleImpact of exercise training on cardiotoxicity and cardiac health outcomes in women with breast cancer anthracycline chemotherapy: a study protocol for a randomized controlled trialpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPage433pt_PT
oaire.citation.titleTrialspt_PT
oaire.citation.volume20pt_PT
person.familyNameAntunes
person.familyNameEsteves
person.familyNameNunes
person.givenNamePedro Miguel da Silva
person.givenNameDulce
person.givenNameCélia
person.identifierR-000-3NA
person.identifier.ciencia-id2811-8FEC-FC77
person.identifier.ciencia-id791C-4AFB-A5FD
person.identifier.ciencia-idAC1F-3CA0-75FE
person.identifier.orcid0000-0002-2511-1984
person.identifier.orcid0000-0002-6368-2577
person.identifier.orcid0000-0003-0167-4851
person.identifier.ridH-1231-2016
person.identifier.scopus-author-id55193154600
person.identifier.scopus-author-id57194580125
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationf1d68326-7cf2-4989-923f-5c3fee7b7060
relation.isAuthorOfPublicationc13e1515-a961-4899-8230-632733bc97a9
relation.isAuthorOfPublication6c089279-689d-4566-b2ee-797ddbefbeab
relation.isAuthorOfPublication.latestForDiscoveryc13e1515-a961-4899-8230-632733bc97a9

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