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Development of a new chitosan hydrogel for wound dressing

2009-10-12Artigo científico Acesso restrito
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dc.contributor.authorRibeiro, MP.
dc.contributor.authorEspiga, Ana
dc.contributor.authorSilva, Daniela
dc.contributor.authorBaptista, Patrícia
dc.contributor.authorHenriques, Joaquim
dc.contributor.authorFerreira, Catarina L.
dc.contributor.authorSilva, Jorge
dc.contributor.authorBorges, João
dc.contributor.authorPires, Eduardo
dc.contributor.authorChaves, Paula
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.date.accessioned2018-03-16T14:15:08Z
dc.date.available2018-03-16T14:15:08Z
dc.date.issued2009-10-12
dc.description.abstractWound healing is a complex process involving an integrated response by many different cell types and growth factors in order to achieve rapid restoration of skin architecture and function. The present study evaluated the applicability of a chitosan hydrogel (CH) as a wound dressing. Scanning electron microscopy analysis was used to characterize CH morphology. Fibroblast cells isolated from rat skin were used to assess the cytotoxicity of the hydrogel. CH was able to promote cell adhesion and proliferation. Cell viability studies showed that the hydrogel and its degradation by-products are noncytotoxic. The evaluation of the applicability of CH in the treatment of dermal burns in Wistar rats was performed by induction of full-thickness transcutaneous dermal wounds. Wound healing was monitored through macroscopic and histological analysis. From macroscopic analysis, the wound beds of the animals treated with CH were considerably smaller than those of the controls. Histological analysis revealed lack of a reactive or a granulomatous inflammatory reaction in skin lesions with CH and the absence of pathological abnormalities in the organs obtained by necropsy, which supported the local and systemic histocompatibility of the biomaterial. The present results suggest that this biomaterial may aid the re-establishment of skin architecture.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRibeiro, M.P., Espiga, A., Silva, D., Baptista, P., Henriques, J., Ferreira, C., Silva, J.C., Borges, J.P., Pires, E., Chaves, P. e Correia, I.J. (2009) “Development of a New Chitosan Hydrogel for Wound Dressing”, Wound Repair and Regeneration, Vol. 17(6), pp. 817-824pt_PT
dc.identifier.doi10.1111/j.1524-475X.2009.00538.xpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4624
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationBolsa de Doutoramento FCT: Desenvolvimento de matrizes de microfibras e nanofibras para regeneração de tecidos cutâneos por fiação húmida e electrofiação [SFRH/BDE/15653/2007]
dc.relationBolsa de Pós-Doutoramento FCT: Estudos estruturais, mecanísticos e funcionais de canais de cálcio membranares [SFRH/BPD/19776/2004]
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/j.1524-475X.2009.00538.x/abstractpt_PT
dc.subjectHydrogelpt_PT
dc.subjectChitosanpt_PT
dc.subjectWound dressingpt_PT
dc.titleDevelopment of a new chitosan hydrogel for wound dressingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberSFRH/BDE/15653/2007
oaire.awardNumberSFRH/BPD/19776/2004
oaire.awardTitleBolsa de Doutoramento FCT: Desenvolvimento de matrizes de microfibras e nanofibras para regeneração de tecidos cutâneos por fiação húmida e electrofiação [SFRH/BDE/15653/2007]
oaire.awardTitleBolsa de Pós-Doutoramento FCT: Estudos estruturais, mecanísticos e funcionais de canais de cálcio membranares [SFRH/BPD/19776/2004]
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBDE%2F15653%2F2007/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F19776%2F2004/PT
oaire.citation.endPage824pt_PT
oaire.citation.startPage817pt_PT
oaire.citation.titleWound Repair and Regenerationpt_PT
oaire.citation.volume17pt_PT
oaire.fundingStreamBolsa de Doutoramento em Empresas (BDE)
oaire.fundingStreamBolsa de Pós-Doutoramento
person.familyNameRibeiro
person.familyNameGarcia Pereira Henriques
person.familyNameProença Valente Ferreira
person.familyNameChaves
person.familyNameCorreia
person.givenNameMaximiano
person.givenNameJoaquim José
person.givenNameCatarina da Luz
person.givenNamePaula
person.givenNameIlídio Joaquim Sobreira
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-idBD11-6497-FD37
person.identifier.ciencia-id3012-4004-172B
person.identifier.ciencia-id0A13-9603-4FC2
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0001-6357-8115
person.identifier.orcid0000-0002-2293-2277
person.identifier.orcid0000-0002-6858-2604
person.identifier.orcid0000-0002-0732-2059
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id26658759200
person.identifier.scopus-author-id7003558877
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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