Repository logo
 
Publication

Development of a new chitosan hydrogel for wound dressing

2009-10-12Journal article Restricted access
Simple item page
dc.contributor.authorRibeiro, MP.
dc.contributor.authorEspiga, Ana
dc.contributor.authorSilva, Daniela
dc.contributor.authorBaptista, Patrícia
dc.contributor.authorHenriques, Joaquim
dc.contributor.authorFerreira, Catarina L.
dc.contributor.authorSilva, Jorge
dc.contributor.authorBorges, João
dc.contributor.authorPires, Eduardo
dc.contributor.authorChaves, Paula
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.date.accessioned2018-03-16T14:15:08Z
dc.date.available2018-03-16T14:15:08Z
dc.date.issued2009-10-12
dc.description.abstractWound healing is a complex process involving an integrated response by many different cell types and growth factors in order to achieve rapid restoration of skin architecture and function. The present study evaluated the applicability of a chitosan hydrogel (CH) as a wound dressing. Scanning electron microscopy analysis was used to characterize CH morphology. Fibroblast cells isolated from rat skin were used to assess the cytotoxicity of the hydrogel. CH was able to promote cell adhesion and proliferation. Cell viability studies showed that the hydrogel and its degradation by-products are noncytotoxic. The evaluation of the applicability of CH in the treatment of dermal burns in Wistar rats was performed by induction of full-thickness transcutaneous dermal wounds. Wound healing was monitored through macroscopic and histological analysis. From macroscopic analysis, the wound beds of the animals treated with CH were considerably smaller than those of the controls. Histological analysis revealed lack of a reactive or a granulomatous inflammatory reaction in skin lesions with CH and the absence of pathological abnormalities in the organs obtained by necropsy, which supported the local and systemic histocompatibility of the biomaterial. The present results suggest that this biomaterial may aid the re-establishment of skin architecture.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRibeiro, M.P., Espiga, A., Silva, D., Baptista, P., Henriques, J., Ferreira, C., Silva, J.C., Borges, J.P., Pires, E., Chaves, P. e Correia, I.J. (2009) “Development of a New Chitosan Hydrogel for Wound Dressing”, Wound Repair and Regeneration, Vol. 17(6), pp. 817-824pt_PT
dc.identifier.doi10.1111/j.1524-475X.2009.00538.xpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4624
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationDESENVOLVIMENTO DE MATRIZES DE MICROFIBRAS E NANOFIBRAS PARA REGENERAÇÃO DE TECIDOS CUTÂNEOS POR FIAÇÃO HÚMIDA E ELECTROFIAÇÃO
dc.relationESTUDOS ESTRUTURAIS, MECANÍSTICOS E FUNCIONAIS DE CANAIS DE CÁLCIO MEMBRANARES
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/j.1524-475X.2009.00538.x/abstractpt_PT
dc.subjectHydrogelpt_PT
dc.subjectChitosanpt_PT
dc.subjectWound dressingpt_PT
dc.titleDevelopment of a new chitosan hydrogel for wound dressingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDESENVOLVIMENTO DE MATRIZES DE MICROFIBRAS E NANOFIBRAS PARA REGENERAÇÃO DE TECIDOS CUTÂNEOS POR FIAÇÃO HÚMIDA E ELECTROFIAÇÃO
oaire.awardTitleESTUDOS ESTRUTURAIS, MECANÍSTICOS E FUNCIONAIS DE CANAIS DE CÁLCIO MEMBRANARES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBDE%2F15653%2F2007/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F19776%2F2004/PT
oaire.citation.endPage824pt_PT
oaire.citation.startPage817pt_PT
oaire.citation.titleWound Repair and Regenerationpt_PT
oaire.citation.volume17pt_PT
person.familyNameRibeiro
person.familyNameGarcia Pereira Henriques
person.familyNameProença Valente Ferreira
person.familyNameChaves
person.familyNameJoaquim Sobreira Correia
person.givenNameMaximiano
person.givenNameJoaquim José
person.givenNameCatarina da Luz
person.givenNamePaula
person.givenNameIlídio
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-idBD11-6497-FD37
person.identifier.ciencia-id3012-4004-172B
person.identifier.ciencia-id0A13-9603-4FC2
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0001-6357-8115
person.identifier.orcid0000-0002-2293-2277
person.identifier.orcid0000-0002-6858-2604
person.identifier.orcid0000-0002-0732-2059
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id26658759200
person.identifier.scopus-author-id7003558877
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3fe7a59f-e867-4bed-bb6e-7d7631330af5
relation.isAuthorOfPublication6e0c1ae0-a6ed-4284-a9b6-93fe8df55bc4
relation.isAuthorOfPublicationdfd20607-afc8-4d68-aabd-50cc04a0331a
relation.isAuthorOfPublication12dd83fa-2f05-418b-8225-25399f2548e1
relation.isAuthorOfPublicationf2c3e779-34a2-4309-950a-80687664c6ad
relation.isAuthorOfPublication.latestForDiscoveryf2c3e779-34a2-4309-950a-80687664c6ad
relation.isProjectOfPublicationa073c2ae-8d7a-42ff-a44d-78dcc5d5b2ce
relation.isProjectOfPublication5b739dfa-0333-4e54-b398-ea9d14184056
relation.isProjectOfPublication.latestForDiscoverya073c2ae-8d7a-42ff-a44d-78dcc5d5b2ce

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
2009 Ribeiro WRR.pdf
Size:
940.66 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FCS - DCM | Documentos por Auto-Depósito