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Renewable Photo-Cross-Linkable Polyester-Based Biomaterials: Synthesis, Characterization, and Cytocompatibility Assessment

2024-10-17Research article Restricted access
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorCernadas, Maria Teresa
dc.contributor.authorPereira, João
dc.contributor.authorMelo, Bruna Daniela Lopes
dc.contributor.authorde Melo-Diogo, Duarte
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.contributor.authorAlves, Patrícia
dc.contributor.authorCalvinho, Paula Cristina Nunes Ferreira
dc.date.accessioned2025-10-02T09:51:46Z
dc.date.available2025-10-02T09:51:46Z
dc.date.issued2024-10-17
dc.description.abstractTThe present work consist of the synthesis of photo-crosslinkable materials, based on unsaturated polyesters (UPs), synthesized from biobased monomers from renewable sources such as itaconic acid and 1,4- butanediol. The UPs were characterized to assess the influence of polycondensation reaction temperature and cross-linking time on their final properties. For this purpose, different UV irradiation exposure periods were tested. Homogeneous, uniform, and transparent films were obtained after 1, 3, and 5 min of UV exposure. These cross-linked films were then characterized. All materials presented high gel content, which was dependent on the reaction’s temperature. The thermal behaviors of the UPs were shown to be similar. In vitro hydrolytic degradation tests showed that the materials can undergo degradation in phosphate-buffered saline (PBS) at pH 7.4 and 37 °C, ensuring their biodegradability over time. Finally, to assess the applicability of the polyesters as biomaterials, their cytocompatibility was determined by using human dermal fibroblasts.eng
dc.identifier.citationCernadas, T., Pereira, J., Melo, B. L., de Melo-Diogo, D., Correia, I. J., Alves, P., & Ferreira, P. (2024). Renewable Photo-Cross-Linkable Polyester-Based Biomaterials: Synthesis, Characterization, and Cytocompatibility Assessment. Biomacromolecules, 25(11), 7134-7145
dc.identifier.doihttps://doi.org/10.1021/acs.biomac.4c00599
dc.identifier.issn1526-4602
dc.identifier.urihttp://hdl.handle.net/10400.6/18939
dc.language.isoeng
dc.peerreviewedyes
dc.publisherAmerican Chemical Society
dc.relationHealth Sciences Research Centre
dc.relationPolymer-based Photocatalystd for Wastewater Treatment through Light-driven Processes
dc.relationBolsa de Doutoramento - Biotecnologia Médica
dc.relationShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy
dc.relationSilk Sericin as an industrial wastewater with valuable biomedical potential
dc.relationThiol-ene click injectable in situ forming hydrogels incorporating graphene: optimization of the polymer-related features for the immuno-photothermal therapy of metastatic breast cancer
dc.relationAssociate Laboratory of Energy, Transports and Aerospace.
dc.relation.hasversionhttps://pubs.acs.org/doi/full/10.1021/acs.biomac.4c00599
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBiomaterials Degradation Materials Nucleic acid structure Organic polymers
dc.titleRenewable Photo-Cross-Linkable Polyester-Based Biomaterials: Synthesis, Characterization, and Cytocompatibility Assessmenteng
dc.typeresearch article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitlePolymer-based Photocatalystd for Wastewater Treatment through Light-driven Processes
oaire.awardTitleBolsa de Doutoramento - Biotecnologia Médica
oaire.awardTitleShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy
oaire.awardTitleSilk Sericin as an industrial wastewater with valuable biomedical potential
oaire.awardTitleThiol-ene click injectable in situ forming hydrogels incorporating graphene: optimization of the polymer-related features for the immuno-photothermal therapy of metastatic breast cancer
oaire.awardTitleAssociate Laboratory of Energy, Transports and Aerospace.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00709%2F2020/PT
oaire.awardURIhttp://hdl.handle.net/10400.6/18938
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/2021.06044.BD/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND4ed/2021.00590.CEECIND%2FCP1661%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBTA-BTA%2F0696%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos de I&D em Todos os Domínios Científicos - 2022/2022.06320.PTDC/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0079%2F2020/PT
oaire.citation.endPage7145
oaire.citation.startPage7134
oaire.citation.titleBiomacromolecules
oaire.citation.volume25
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_CENTRO
oaire.fundingStreamCEEC IND4ed
oaire.fundingStream3599-PPCDT
oaire.fundingStreamConcurso de Projetos de I&D em Todos os Domínios Científicos - 2022
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCernadas
person.familyNameMelo
person.familyNamede Melo-Diogo
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person.givenNameMaria Teresa
person.givenNameBruna Daniela Lopes
person.givenNameDuarte
person.givenNameIlídio Joaquim Sobreira
person.givenNamePatrícia
person.givenNamePaula Cristina Nunes Ferreira
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person.identifier.ciencia-idA119-FFB8-0899
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person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0002-8943-8329
person.identifier.orcid0000-0003-3393-4427
person.identifier.ridI-1004-2013
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person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id12762379800
person.identifier.scopus-author-id55321888200
project.funder.identifierhttp://doi.org/10.13039/501100001871
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