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Clinical isolates of Acinetobacter baumannii from a Portuguese hospital: PFGE characterization, antibiotic susceptibility and biofilm-forming ability

dc.contributor.authorDuarte, Andreia
dc.contributor.authorFerreira, Susana
dc.contributor.authorAlmeida, Sofia
dc.contributor.authorDomingues, F.C.
dc.date.accessioned2020-01-29T14:24:59Z
dc.date.available2020-01-29T14:24:59Z
dc.date.issued2016
dc.description.abstractAcinetobacter baumannii is an emerging pathogen associated with nosocomial infections that in addition has shown an increasing resistance to antibiotics. In this work the genetic diversity of A. baumannii isolates from a Portuguese hospital, their antibiotic resistance profiles and ability to form biofilms was studied. Seventy-nine clinical A. baumannii isolates were characterized by pulsed-field gel electrophoresis (PFGE) with 9 different PFGE profiles being obtained. Concerning the antimicrobial susceptibility, all A. baumannii isolates were resistant to 12 of the 17 tested antibiotics and classified as multidrug-resistant (MDR). In addition, 74.7% of the isolates showed biofilm formation ability, however no statistical significance with antibiotic resistance was observed. In contrast, urine samples isolates were more likely to form biofilms than strains isolated from other sources. Our findings highlight the high number of MDR A. baumannii isolates and the importance of the formation of biofilms as a potential virulence factor.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.cimid.2016.02.002pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/8890
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationStrategic Project - UI 709 - 2011-2012
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0147957116300157?via%3Dihubpt_PT
dc.subjectAcinetobacter baumanniipt_PT
dc.subjectPFGEpt_PT
dc.subjectAntibiotic resistancept_PT
dc.subjectBiofilmapt_PT
dc.titleClinical isolates of Acinetobacter baumannii from a Portuguese hospital: PFGE characterization, antibiotic susceptibility and biofilm-forming abilitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 709 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PTDC%2FAGR-ALI%2F121876%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FSAU%2FUI0709%2F2011/PT
oaire.citation.endPage33pt_PT
oaire.citation.startPage29pt_PT
oaire.citation.titleComparative Immunology, Microbiology and Infectious Diseasespt_PT
oaire.citation.volume45pt_PT
oaire.fundingStreamCOMPETE
oaire.fundingStream6820 - DCRRNI ID
person.familyNameDuarte
person.familyNameFerreira
person.familyNameDomingues
person.givenNameAndreia
person.givenNameSusana
person.givenNameFernanda
person.identifier.ciencia-id9614-49D7-574A
person.identifier.ciencia-idF718-3569-E911
person.identifier.ciencia-id6514-0498-3E8F
person.identifier.orcid0000-0001-9036-0170
person.identifier.orcid0000-0001-8308-2862
person.identifier.orcid0000-0002-9540-0853
person.identifier.ridF-1563-2013
person.identifier.ridA-6810-2016
person.identifier.ridN-7295-2013
person.identifier.scopus-author-id54794112100
person.identifier.scopus-author-id34874668400
person.identifier.scopus-author-id10139481400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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