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3D tumor spheroids: an overview on the tools and techniques used for their analysis

2016-11-11Journal article Restricted access
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dc.contributor.authorCosta, Elisabete C.
dc.contributor.authorMoreira, André
dc.contributor.authorDiogo, Duarte Miguel de Melo
dc.contributor.authorGaspar, V. M.
dc.contributor.authorCarvalho, Marco António Paulo de
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2018-03-21T15:40:51Z
dc.date.available2018-03-21T15:40:51Z
dc.date.issued2016-11-11
dc.description.abstractIn comparison with 2D cell culture models, 3D spheroids are able to accurately mimic some features of solid tumors, such as their spatial architecture, physiological responses, secretion of soluble mediators, gene expression patterns and drug resistance mechanisms. These unique characteristics highlight the potential of 3D cellular aggregates to be used as in vitro models for screening new anticancer therapeutics, both at a small and large scale. Nevertheless, few reports have focused on describing the tools and techniques currently available to extract significant biological data from these models. Such information will be fundamental to drug and therapeutic discovery process using 3D cell culture models. The present review provides an overview of the techniques that can be employed to characterize and evaluate the efficacy of anticancer therapeutics in 3D tumor spheroids.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.biotechadv.2016.11.002pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4690
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationHealth Sciences Research Centre
dc.relation3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
dc.relationDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
dc.relationMULTIFUNCTIONAL GRAPHENE-OXIDE NANOCARRIERS FOR DRUG DELIVERY AND PHOTOTHERMAL THERAPY OF LUNG CANCER
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0734975016301379pt_PT
dc.subject3D tumor spheroidspt_PT
dc.subjectCancer therapypt_PT
dc.subjectIn vitro modelspt_PT
dc.subjectMethodologiespt_PT
dc.subjectTherapeutic screeningpt_PT
dc.title3D tumor spheroids: an overview on the tools and techniques used for their analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitle3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
oaire.awardTitleDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
oaire.awardTitleMULTIFUNCTIONAL GRAPHENE-OXIDE NANOCARRIERS FOR DRUG DELIVERY AND PHOTOTHERMAL THERAPY OF LUNG CANCER
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F103507%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109482%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F103506%2F2014/PT
oaire.citation.endPage1441pt_PT
oaire.citation.startPage1427pt_PT
oaire.citation.titleBiotechnology Advancespt_PT
oaire.citation.volume34pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_CENTRO
person.familyNameda Rocha Costa
person.familyNameMoreira
person.familyNameMiguel de Melo Diogo
person.familyNameGaspar
person.familyNameJoaquim Sobreira Correia
person.givenNameElisabete Cristina
person.givenNameAndré Ferreira
person.givenNameDuarte
person.givenNameVítor
person.givenNameIlídio
person.identifier1161643
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person.identifier.ciencia-idB314-4CF0-6633
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-id9C10-9BD8-634E
person.identifier.ciencia-id6F16-3640-73E3
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-0490-0095
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0001-9984-3603
person.identifier.orcid0000-0002-0372-2493
person.identifier.orcid0000-0003-1613-9675
person.identifier.ridB-1602-2017
person.identifier.scopus-author-id55805850100
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id56266511300
person.identifier.scopus-author-id36968590900
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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