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Amino Acid-Based Material for the Complementary Therapy of Decubitus Ulcers

dc.contributor.authorNogueira, Frederico
dc.contributor.authorGouveia, Isabel C.
dc.date.accessioned2019-11-04T12:12:07Z
dc.date.available2019-11-04T12:12:07Z
dc.date.issued2017-04
dc.description.abstractChronic wounds, pressure sores, lesions, and infections of microbial origin in bedridden, paralyzed, or malnutrition patients remain the object of study of many researchers. A variety of factors behind the development of these disorders are related to the patient's immune system, making it unable to respond effectively to the treatment of the wound. These factors can be properly controlled, giving particular importance to the ethiology and stage of the wound, as well as the time periods corresponding to the replacement of the dressings. The present research reports a novel foam/soft material, L-Cys-g-PCL, with an application for decubitus/pressure ulcers, especially for wounds with a difficult healing process due to infections and constant oxidation of the soft tissues. During this work, the interactions between S. aureus and L-Cys-g-PCL foam were studied under conditions that simulate decubitus ulcers; namely, pH and exudate. The effects of duration of grafting (1 or 8 h) and pH (7.0 and 8.9) on wettability, surface energy, swelling, and porosity were also evaluated. Results showed an effective microbicidal activity exhibiting an inhibition ratio of 99.73% against S. aureus. This new L-Cys-g-PCL soft material showed saftey to contact skin, ability to be shaped to fill in sunken holes (craters) - pressure ulcers stage III - and to act as a smart material responsive to pH, which can be tailored to develop better swelling properties at alkaline pH where exudates are normally higher, so as to address exudate self-cleaning and prevention of desiccation..pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.4014/jmb.1609.09061pt_PT
dc.identifier.issn1738-8872
dc.identifier.urihttp://hdl.handle.net/10400.6/7494
dc.language.isoengpt_PT
dc.relationCOVALENT AND NON-COVALENT STRATEGIES FOR SURFACE MODIFICATION OF DIFFERENT TEXTILE MATERIALS WITH ANTIMICROBIAL PROPERTIES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectL-Cysteinept_PT
dc.subjectAntimicrobial agentspt_PT
dc.subjectChronic woundspt_PT
dc.subjectAminolysispt_PT
dc.subjectStaphylococcus aureuspt_PT
dc.titleAmino Acid-Based Material for the Complementary Therapy of Decubitus Ulcerspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCOVALENT AND NON-COVALENT STRATEGIES FOR SURFACE MODIFICATION OF DIFFERENT TEXTILE MATERIALS WITH ANTIMICROBIAL PROPERTIES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F91444%2F2012/PT
oaire.citation.endPage758pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage747pt_PT
oaire.citation.titleJournal of Microbiology and Biotechnologypt_PT
oaire.citation.volume27pt_PT
person.familyNameSequeira Nogueira
person.familyNameGouveia
person.givenNameFrederico Álvaro
person.givenNameIsabel Cristina
person.identifierH-2141-2015
person.identifier626131
person.identifier.ciencia-id7119-F02C-91CE
person.identifier.ciencia-id5711-86D0-A54B
person.identifier.orcid0000-0003-2229-8920
person.identifier.orcid0000-0003-3290-9529
person.identifier.ridK-1651-2014
person.identifier.scopus-author-id56194664600
person.identifier.scopus-author-id24328741500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationc4fd84d8-dab6-4f00-ad8c-3f66a733ac3d
relation.isAuthorOfPublicationa2024ec6-6edb-47e5-b8a0-594066a5036c
relation.isAuthorOfPublication.latestForDiscoveryc4fd84d8-dab6-4f00-ad8c-3f66a733ac3d
relation.isProjectOfPublicatione9a3bbb4-4d3b-4b06-810d-32a7522f4dd2
relation.isProjectOfPublication.latestForDiscoverye9a3bbb4-4d3b-4b06-810d-32a7522f4dd2

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