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Sweet cherries from Fundão possess antidiabetic potential and protect human erythrocytes against oxidative damage

2017Journal article Open access
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dc.contributor.authorGonçalves, Ana C.
dc.contributor.authorBento, Catarina Pereira
dc.contributor.authorSilva, Branca M.
dc.contributor.authorSilva, Luís R.
dc.date.accessioned2020-02-17T11:38:16Z
dc.date.available2020-02-17T11:38:16Z
dc.date.issued2017
dc.description.abstractCherries are one of the most appreciated summer fruits due to their attractive colour, sweet taste, high water content, low level of calories and composition in bioactive compounds which, in turn, are important to prevent some pathologies like diabetes, cardiovascular diseases and cancer. In this work we evaluated the phenolic profile and biological potential of 5 varieties of sweet cherries from Fundão region (Portugal) (Saco, Sweetheart, Satin, Maring and Hedelfinger). A total of 23 phenolic compounds were identified by LC-DAD and distributed by the several classes: 6 anthocyanins, 1 hydroxybenzoic acid, 8 hydroxycinnamic acids, 3 flavan-3-ols and 5 flavonols. Maring revealed higher contents in anthocyanins, while Hedelfinger was the richest in non-coloured phenolics. The antioxidant capacity was evaluated against DPPH and nitric oxide radicals. Hedelfinger was the most active against DPPH• (IC50=12.1μg/mL) and Maring against nitric oxide (IC50=140.9μg/mL). Afterwards, antidiabetic capacity was evaluated through the inhibition of α-glucosidase activity, pointing Hedelfinger as the most active (IC50=10.3μg/mL). The capacity of Saco extracts to inhibit the hemoglobin oxidation and the hemolysis of human erythrocytes was also evaluated. Both assays revealed a concentration-dependent inhibitory effect (IC50=38.6μg/mL and IC50=73.0μg/mL, respectively). The results obtained in this study allow us to conclude that sweet cherries possess a great biological potential, and further investigation should be done to promote commercialization and encourage its use in food supplements and in new pharmaceutical and nutraceutical applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.foodres.2017.02.023pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/9283
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationDevelopment of biofertilizers to increase the production of bioactive compounds in vegetables
dc.subjectAnthocyaninspt_PT
dc.subjectAntioxidantspt_PT
dc.subjectErythrocytespt_PT
dc.subjectFruitpt_PT
dc.subjectGlycoside Hydrolase Inhibitorspt_PT
dc.subjectHumanspt_PT
dc.subjectHypoglycemic Agentspt_PT
dc.subjectOxidative Stresspt_PT
dc.subjectPhenolspt_PT
dc.subjectPlant Extractspt_PT
dc.subjectPortugalpt_PT
dc.subjectProtective Agentspt_PT
dc.subjectPrunus aviumpt_PT
dc.titleSweet cherries from Fundão possess antidiabetic potential and protect human erythrocytes against oxidative damagept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of biofertilizers to increase the production of bioactive compounds in vegetables
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBPD%2F105263%2F2014/PT
oaire.citation.endPage100pt_PT
oaire.citation.startPage91pt_PT
oaire.citation.titleFood Research Internationalpt_PT
oaire.citation.volume95pt_PT
oaire.fundingStream5876
oaire.fundingStreamFARH
person.familyNameGonçalves
person.familyNameBento
person.familyNameSilva
person.familyNameLopes Rodrigues da Silva
person.givenNameAna Carolina Almeida
person.givenNameCatarina Pereira
person.givenNameBranca Maria
person.givenNameLuís Manuel
person.identifier541828
person.identifier1033309
person.identifier.ciencia-id551A-A2EA-4E86
person.identifier.ciencia-idBD1F-B24D-89A9
person.identifier.ciencia-idFF13-65B0-519A
person.identifier.orcid0000-0001-7795-795X
person.identifier.orcid0000-0001-8098-2531
person.identifier.orcid0000-0002-5610-8024
person.identifier.orcid0000-0001-5264-3516
person.identifier.ridAAX-2647-2021
person.identifier.scopus-author-id7102086139
person.identifier.scopus-author-id7005615589
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication295f81e8-c717-4c65-b494-9504bd226d18
relation.isAuthorOfPublication46ff84d3-2ab2-43a2-8c67-55ab1d2ddf35
relation.isAuthorOfPublication2c14722e-0257-4c40-ae19-9e71df94ab4f
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relation.isAuthorOfPublication.latestForDiscovery295f81e8-c717-4c65-b494-9504bd226d18
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