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Sweet Cherries as Anti-Cancer Agents: From Bioactive Compounds to Function

2021Journal article Open access
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dc.contributor.authorFonseca, Lara R. S.
dc.contributor.authorSilva, Gonçalo R.
dc.contributor.authorLuís, Ângelo
dc.contributor.authorCardoso, Henrique J.
dc.contributor.authorCorreia, Sara
dc.contributor.authorVaz, CV
dc.contributor.authorDuarte, Ana Paula
dc.contributor.authorSocorro, Sílvia
dc.date.accessioned2021-11-08T09:58:34Z
dc.date.available2021-11-08T09:58:34Z
dc.date.issued2021
dc.description.abstractSweet cherries (Prunus avium L.) are among the most appreciated fruits worldwide because of their organoleptic properties and nutritional value. The accurate phytochemical composition and nutritional value of sweet cherries depends on the climatic region, cultivar, and bioaccessibility and bioavailability of specific compounds. Nevertheless, sweet cherry extracts are highly enriched in several phenolic compounds with relevant bioactivity. Over the years, technological advances in chemical analysis and fields as varied as proteomics, genomics and bioinformatics, have allowed the detailed characterization of the sweet cherry bioactive phytonutrients and their biological function. In this context, the effect of sweet cherries on suppressing important events in the carcinogenic process, such as oxidative stress and inflammation, was widely documented. Interestingly, results from our research group and others have widened the action of sweet cherries to many hallmarks of cancer, namely metabolic reprogramming. The present review discusses the anticarcinogenic potential of sweet cherries by addressing their phytochemical composition, the bioaccessibility and bioavailability of specific bioactive compounds, and the existing knowledge concerning the effects against oxidative stress, chronic inflammation, deregulated cell proliferation and apoptosis, invasion and metastization, and metabolic alterations. Globally, this review highlights the prospective use of sweet cherries as a dietary supplement or in cancer treatment.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/molecules26102941pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/11243
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationHealth Sciences Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSweet cherriespt_PT
dc.subjectAnthocyaninspt_PT
dc.subjectAnti-cancer agentspt_PT
dc.subjectOxidative stresspt_PT
dc.subjectInflammationpt_PT
dc.subjectProliferationpt_PT
dc.subjectApoptosispt_PT
dc.subjectInvasionpt_PT
dc.subjectMetastizationpt_PT
dc.subjectMetabolic reprogrammingpt_PT
dc.titleSweet Cherries as Anti-Cancer Agents: From Bioactive Compounds to Functionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.citation.issue10pt_PT
oaire.citation.startPage2941pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume26pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFonseca
person.familyNameSilva
person.familyNameSantos Luís
person.familyNameCardoso
person.familyNameCorreia
person.familyNameVaz
person.familyNameDuarte
person.familyNameSocorro
person.givenNameLara R. S.
person.givenNameGonçalo
person.givenNameÂngelo Filipe
person.givenNameHenrique
person.givenNameSara
person.givenNameCátia
person.givenNameAna Paula
person.givenNameSílvia Cristina da Cruz Marques
person.identifier1255684
person.identifierhttps://scholar.google.pt/citations?user=PA3L_h8AAAAJ&hl=pt-PT
person.identifier.ciencia-id1618-46EE-4DA4
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person.identifier.ciencia-idBC15-D376-80FE
person.identifier.ciencia-idAB17-5C25-1F2C
person.identifier.orcid0000-0002-8789-4048
person.identifier.orcid0000-0002-1252-2709
person.identifier.orcid0000-0003-0712-6522
person.identifier.orcid0000-0002-5750-2875
person.identifier.orcid0000-0001-9199-8360
person.identifier.orcid0000-0002-7720-4234
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person.identifier.orcid0000-0001-8181-488X
person.identifier.ridB-5904-2009
person.identifier.scopus-author-id56421799300
person.identifier.scopus-author-id7004157751
person.identifier.scopus-author-id7102602131
person.identifier.scopus-author-id23097994600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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