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Thermo- and pH-responsive nano-in-micro particles for combinatorial drug delivery to cancer cells

2017-03-25Journal article Restricted access
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dc.contributor.authorMoreira, André
dc.contributor.authorDias, Diana Rodrigues
dc.contributor.authorCosta, Elisabete C.
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.date.accessioned2018-03-22T09:07:18Z
dc.date.available2018-03-22T09:07:18Z
dc.date.issued2017-03-25
dc.description.abstractDrug combinatorial therapy has been gaining the scientific community attention as a suitable approach to increase treatments efficacy and promote cancer eradication. In this study, a new pH- and thermo- responsive carrier was developed by combining doxorubicin-loaded gold-core silica shell nanorods with salicylic acid loaded poly (lactic-co-glycolic acid) based microparticles (NIMPS). The obtained results showed that the drugs and nanorods release could be triggered by the near-infrared (NIR) laser irradiation or by the exposition to an acidic environment. The in vitro 2D cell studies showed that the NIMPS are biocompatible and easily uptaken by HeLa cells. In addition, 3D cell culture models revealed that the NIMPS administration, combined with the NIR laser irradiation, was capable of reducing the size of the HeLa spheroids up to 48%. Overall, the attained data support the application of the nano-in-micro spheres as a dual stimuli responsive drug carrier system for the local administration of combined therapies to cervical cancer cells.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMoreira, A. F., Dias, D. R., Costa, E. C., e Correia, I.J. (2017). “Thermo-and pH-responsive nano-in-micro particles for combinatorial drug delivery to cancer cells.” European Journal of Pharmaceutical Sciences, Vol.104, pp.42-51pt_PT
dc.identifier.doi10.1016/j.ejps.2017.03.033pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4698
dc.language.isospapt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationHealth Sciences Research Centre
dc.relationDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
dc.relation3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0928098717301689pt_PT
dc.subjectPLGA microparticlespt_PT
dc.subjectpH-Responsivept_PT
dc.subjectThermo-responsivept_PT
dc.subjectDrug combinationpt_PT
dc.titleThermo- and pH-responsive nano-in-micro particles for combinatorial drug delivery to cancer cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
oaire.awardTitle3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109482%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F103507%2F2014/PT
oaire.citation.endPage51pt_PT
oaire.citation.startPage42pt_PT
oaire.citation.titleEuropean Journal of Pharmaceutical Sciencespt_PT
oaire.citation.volume104pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_CENTRO
person.familyNameMoreira
person.familyNameda Rocha Costa
person.familyNameJoaquim Sobreira Correia
person.givenNameAndré Ferreira
person.givenNameElisabete Cristina
person.givenNameIlídio
person.identifier1161643
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-idB314-4CF0-6633
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0002-0490-0095
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id55805850100
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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