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Injectable hydrogels for the delivery of nanomaterials for cancer combinatorial photothermal therapy

2023-07-17Journal article Embargoed access
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dc.contributor.authorLima-Sousa, Rita
dc.contributor.authorAlves, Cátia
dc.contributor.authorMelo, Bruna L.
dc.contributor.authorCosta, Francisco J. P.
dc.contributor.authorNave, Micaela
dc.contributor.authorMoreira, André F.
dc.contributor.authorMendonça, António
dc.contributor.authorCorreia, I.J.
dc.contributor.authorde Melo-Diogo, Duarte
dc.date.accessioned2023-09-14T09:01:59Z
dc.date.embargo2025-09-14
dc.date.issued2023-07-17
dc.description.abstractProgress in the nanotechnology field has led to the development of a new class of materials capable of producing a temperature increase triggered by near infrared light. These photothermal nanostructures have been extensively explored in the ablation of cancer cells. Nevertheless, the available data in the literature have exposed that systemically administered nanomaterials have a poor tumor-homing capacity, hindering their full therapeutic potential. This paradigm shift has propelled the development of new injectable hydrogels for the local delivery of nanomaterials aimed at cancer photothermal therapy. These hydrogels can be assembled at the tumor site after injection (in situ forming) or can undergo a gel–sol–gel transition during injection (shear-thinning/self-healing). Besides incorporating photothermal nanostructures, these injectable hydrogels can also incorporate or be combined with other agents, paving the way for an improved therapeutic outcome. This review analyses the application of injectable hydrogels for the local delivery of nanomaterials aimed at cancer photothermal therapy as well as their combination with photodynamic-, chemo-, immuno- and radio-therapies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1039/D3BM00845Bpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/13422
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherRSCpt_PT
dc.relationSilk Sericin as an industrial wastewater with valuable biomedical potential
dc.relationShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy
dc.relationInjectable in situ forming graphene-based hydrogels for double immune checkpoint inhibitor photothermal therapy
dc.relationDevelopment of a responsive multi-layer microneedle patch for the sequential PTT/PDT and immunotherapy of invasive breast cancer
dc.relation.publisherversionhttps://pubs.rsc.org/en/content/articlelanding/2023/bm/d3bm00845bpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleInjectable hydrogels for the delivery of nanomaterials for cancer combinatorial photothermal therapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSilk Sericin as an industrial wastewater with valuable biomedical potential
oaire.awardTitleShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy
oaire.awardTitleInjectable in situ forming graphene-based hydrogels for double immune checkpoint inhibitor photothermal therapy
oaire.awardTitleDevelopment of a responsive multi-layer microneedle patch for the sequential PTT/PDT and immunotherapy of invasive breast cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/2022.06320.PTDC/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBTA-BTA%2F0696%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND4ed/2021.00590.CEECIND%2FCP1661%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F144922%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F145386%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/2021.06044.BD/PT
oaire.citation.conferencePlaceUKpt_PT
oaire.citation.endPage6108pt_PT
oaire.citation.issue18pt_PT
oaire.citation.startPage6082pt_PT
oaire.citation.titleBiomaterials Sciencept_PT
oaire.citation.volume11pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamCEEC IND4ed
oaire.fundingStreamPOR_CENTRO
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person.familyNameSousa
person.familyNameAlves
person.familyNameLopes Melo
person.familyNamePalácio Costa
person.familyNameNave
person.familyNameMoreira
person.familyNameMendonça
person.familyNameJoaquim Sobreira Correia
person.familyNameMiguel de Melo Diogo
person.givenNameAna Rita Lima
person.givenNameCátia Gomes
person.givenNameBruna Daniela
person.givenNameFrancisco José
person.givenNameMicaela
person.givenNameAndré Ferreira
person.givenNameAntónio
person.givenNameIlídio
person.givenNameDuarte
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person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0001-8069-0440
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0001-9984-3603
person.identifier.ridB-1125-2019
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person.identifier.scopus-author-id57201215315
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person.identifier.scopus-author-id56890866600
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person.identifier.scopus-author-id56266511300
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctOs copyrights foram cedidos à editorapt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
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