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Production and Characterization of a Pullulan-Based Facial Mask Incorporating Grape Seed Flour Extract for Cosmeceutical Applications

2025-12-08Artigo científico Acesso aberto
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datacite.subject.fosCiências Médicas::Ciências da Saúde
dc.contributor.authorFerreira, Ester
dc.contributor.authorEncarnação, Bárbara
dc.contributor.authorCascalheira, José Francisco
dc.contributor.authorFerreira, Susana
dc.contributor.authorRamos, Ana
dc.contributor.authorLuís, Ângelo
dc.contributor.authorGallardo, Eugenia
dc.contributor.authorDomingues, Fernanda
dc.contributor.editorMagni, Chiara
dc.date.accessioned2026-02-06T16:32:59Z
dc.date.available2026-02-06T16:32:59Z
dc.date.issued2025-12-08
dc.description.abstractThis study aimed to develop and characterize an eco-friendly facial mask based on the pullulan biopolymer incorporating grape seed flour extract, a sustainable source of polyphenols. The extract was characterized by its phenolic content, antioxidant capacity, enzyme inhibition and antimicrobial activity. High total phenolic and flavonoid contents, along with the presence of -resveratrol, conferred strong antioxidant activity. The extract effectively inhibited tyrosinase and elastase enzymes, indicating its anti-aging potential, and exhibited antimicrobial effects particularly against . The incorporation of the extract in pullulan films increased thickness and coloration while maintaining transparency and improving barrier properties. The bioactive films showed strong antioxidant activity and displayed selective antibacterial activity against , including MRSA strains. A facial mask prototype was successfully produced, demonstrating flexibility, solubility, and potential for topical applications. Overall, the developed pullulan-grape seed extract films exhibit multifunctional cosmeceutical potential combining antioxidant, antimicrobial, and anti-aging effects with sustainable valorization of wine industry by-products.eng
dc.description.sponsorshipEster Ferreira acknowledges a cotutelle PhD fellowship from Fundação para a Ciência e a Tecnologia (FCT) (Reference: 2024.11513.PRT) within the scope of UNITA Alliance.
dc.identifier.citationFerreira, E., Encarnação, B., Cascalheira, J. F., Gallardo, E., Ferreira, S., Ramos, A., Domingues, F., & Luís, Â. (2025). Production and Characterization of a Pullulan-Based Facial Mask Incorporating Grape Seed Flour Extract for Cosmeceutical Applications. International Journal of Molecular Sciences, 26(24), 11845. https://doi.org/10.3390/ijms262411845
dc.identifier.doi10.3390/ijms262411845
dc.identifier.issn1422-0067
dc.identifier.other41465274
dc.identifier.urihttp://hdl.handle.net/10400.6/19873
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationHealth Sciences Research Centre [UIDB/00709/2020]
dc.relationCICS-UBI [UIDP/00709/2020]
dc.relationHealth Sciences Research Centre [UIDP/00709/2020]
dc.relationFiber Materials and Environmental Technologies
dc.relation.hasversionhttps://www.mdpi.com/1422-0067/26/24/11845
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectantimicrobial activity
dc.subjectantioxidant activity
dc.subjectelastase
dc.subjectfacial mask
dc.subjectgrape seed
dc.subjectpullulan
dc.subjectresveratrol
dc.subjecttyrosinase
dc.titleProduction and Characterization of a Pullulan-Based Facial Mask Incorporating Grape Seed Flour Extract for Cosmeceutical Applicationspor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre [UIDB/00709/2020]
oaire.awardTitleCICS-UBI [UIDP/00709/2020]
oaire.awardTitleHealth Sciences Research Centre [UIDP/00709/2020]
oaire.awardTitleFiber Materials and Environmental Technologies
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00195%2F2013/PT
oaire.citation.titleInternational Journal of Molecular Sciences
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Programático
oaire.fundingStream6817 - DCRRNI ID
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oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
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person.givenNameEster Fernanda
person.givenNameJosé Francisco da Silva
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person.givenNameAna Maria Matos
person.givenNameÂngelo Filipe Santos
person.givenNameEugenia
person.givenNameFernanda
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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