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Photocrosslinkable electrospun fiber meshes for tissue engineering applications

2017-10-12Journal article Restricted access
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dc.contributor.authorFerreira, Paula
dc.contributor.authorSantos, PatrĆ­cia
dc.contributor.authorAlves, P.
dc.contributor.authorCarvalho, Marco AntĆ³nio Paulo de
dc.contributor.authorSĆ”, Kevin
dc.contributor.authorMiguel, SĆ³nia P.
dc.contributor.authorCorreia, IlĆ­dio Joaquim Sobreira
dc.contributor.authorCoimbra, ļ»æPatrĆ­cia Manuela Almeida
dc.date.accessioned2018-03-22T09:30:40Z
dc.date.available2018-03-22T09:30:40Z
dc.date.issued2017-10-12
dc.description.abstractElectrospun polymeric meshes are known to exhibit promising properties for the regeneration of several soft tissues. Herein, electrospun polymeric meshes were prepared from blends of polycaprolactone and functionalized gelatin. The meshes were then photocrosslinked under UV light using IrgacureĀ® 2959 as the photoinitiator, aiming to improve membranesā€™ stability in biological fluids. Moreover, meshes suitability to be used as vascular grafts was evaluated by characterizing their chemical/physical properties as well as their haemo and biocompatibility in vitro. The obtained results show that the blended polymeric meshes are biodegradable and those with a higher content of gelatin display a lower water contact angle. Blood compatibility studies showed that the photocrosslinked membranes are haemocompatible, i.e. they display low values of thrombogenicity and do not trigger any haemolytic effect. Also, Normal Human Dermal Fibroblasts cells were incubated in the presence of the produced membranes and they were able to adhere and proliferate, thus revealing the biocompatibility of the photocrosslinked meshes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFerreira, P., Santos, P., Alves, P., Carvalho, M. P., de SĆ”, K. D., Miguel, S. P., Correia, I. J. e Coimbra, P. (2017). ā€œPhotocrosslinkable electrospun fiber meshes for tissue engineering applications.ā€ European Polymer Journal, Vol. 97, pp.210-219pt_PT
dc.identifier.doi10.1016/j.eurpolymj.2017.10.018pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4702
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationUTILIZAƇƃO DE ENXERTOS DE OSSO ALƓGENO E MATERIAIS DERIVADOS DO SEU PROCESSAMENTO NA PREPARAƇƃO DE SISTEMAS DE LIBERTAƇƃO CONTROLADA E LOCALIZADA DE ANTIBIƓTICOS PARA APLICAƇƕES EM CIRURGIA ORTOPƉDICA
dc.relationDEVELOPMENT OF NEW STIMULI-RESPONSIVE POLYMER-LIPOSOME COMPLEXES BY LIVING RADICAL POLYMERIZATION AND ā€œCLICK CHEMISTRYā€
dc.relationDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
dc.relationPHARMACOLOGICALLY ACTIVE BIOADHESIVE DESIGNED FOR WOUND CLOSURE
dc.relationHealth Sciences Research Centre
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0014305717315355pt_PT
dc.subjectElectrospinningpt_PT
dc.subjectPhotocrosslinkingpt_PT
dc.subjectScaffoldspt_PT
dc.subjectHaemocompatibilitypt_PT
dc.subjectBiocompatibilitypt_PT
dc.titlePhotocrosslinkable electrospun fiber meshes for tissue engineering applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleUTILIZAƇƃO DE ENXERTOS DE OSSO ALƓGENO E MATERIAIS DERIVADOS DO SEU PROCESSAMENTO NA PREPARAƇƃO DE SISTEMAS DE LIBERTAƇƃO CONTROLADA E LOCALIZADA DE ANTIBIƓTICOS PARA APLICAƇƕES EM CIRURGIA ORTOPƉDICA
oaire.awardTitleDEVELOPMENT OF NEW STIMULI-RESPONSIVE POLYMER-LIPOSOME COMPLEXES BY LIVING RADICAL POLYMERIZATION AND ā€œCLICK CHEMISTRYā€
oaire.awardTitleDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
oaire.awardTitlePHARMACOLOGICALLY ACTIVE BIOADHESIVE DESIGNED FOR WOUND CLOSURE
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBPD%2F73367%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F69410%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109563%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBPD%2F86338%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PT
oaire.citation.endPage219pt_PT
oaire.citation.startPage210pt_PT
oaire.citation.titleEuropean Polymer Journalpt_PT
oaire.citation.volume97pt_PT
oaire.fundingStreamFARH
oaire.fundingStreamPOR_CENTRO
oaire.fundingStreamOE
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCalvinho
person.familyNameAlves
person.familyNameSĆ”
person.familyNamePereira Miguel
person.familyNameCorreia
person.familyNameAlmeida Coimbra
person.givenNamePaula Cristina Nunes Ferreira
person.givenNamePatrĆ­cia
person.givenNameKevin
person.givenNameSĆ³nia Alexandra
person.givenNameIlĆ­dio Joaquim Sobreira
person.givenNamePatrĆ­cia Manuela
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person.identifier.ciencia-idA119-FFB8-0899
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person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id111E-0CE2-0C3E
person.identifier.orcid0000-0003-3393-4427
person.identifier.orcid0000-0002-8943-8329
person.identifier.orcid0000-0002-7153-3272
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0003-1613-9675
person.identifier.ridI-1004-2013
person.identifier.scopus-author-id55321888200
person.identifier.scopus-author-id12762379800
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundaĆ§Ć£o para a CiĆŖncia e a Tecnologia
project.funder.nameFundaĆ§Ć£o para a CiĆŖncia e a Tecnologia
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project.funder.nameFundaĆ§Ć£o para a CiĆŖncia e a Tecnologia
rcaap.embargofctCopyright cedido Ć  editora no momento da publicaĆ§Ć£opt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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