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Antimicrobial and antioxidant surface modification toward a new silk-fibroin (SF)-l-Cysteine material for skin disease management

2016Journal article Open access
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dc.contributor.authorNogueira, Frederico
dc.contributor.authorGranadeiro, Luiza Breitenfeld
dc.contributor.authorMouro, Cláudia
dc.contributor.authorGouveia, Isabel C.
dc.date.accessioned2019-11-04T12:26:14Z
dc.date.available2019-11-04T12:26:14Z
dc.date.issued2016
dc.description.abstractA novel dressing material – silk fibroin fabric (SF)-l-Cysteine (l-Cys) – is here developed to be used asstandard treatment for atopic dermatitis (AD), which combines comfort, thermic, and tensile strengthproperties of silk materials with antioxidant and antimicrobial effects of l-Cys. A careful understand-ing about the linking strategies is needed in order not to compromise the bioavailability of l-Cys anddeplenish its bioactivity. Durability was also addressed through washing cycles and compared with hos-pital requirements, according to international Standard EN ISO 105-C06:2010. The present research alsoanalyze the interactions between Staphylococcus aureus and SF-l-Cys under simulating conditions of ADand demonstrated the effectiveness of a double covalent grafting, with the importance of SF tyrosine(Tyr) covalent linkage with l-Cys (SF-g-l-Cys/Tyr-g-l-Cys) even after several washing cycles, twenty five,whereas for a disposable application a single covalent mechanism of grafting l-Cys proved to be suffi-cient (SF-g-l-Cys). Results showed effective antimicrobial activities exhibiting higher inhibition ratios of98.65% for SF-g-l-Cys after 5 washing cycles, whereas 97.55% for SF-g-l-Cys/Tyr-g-l-Cys after 25 washingcycles, both at pH 9.5 grafting strategy. Furthermore, it is also reported a non-protumoral effect of l-Cys. Anew advance is herein achieved at the world of medical antimicrobial textiles tailored to address woundmoisture environment and exudate self-cleaning, which may open novel applications as complementarytherapy for AD disease.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.apsusc.2015.12.174pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/7496
dc.language.isoengpt_PT
dc.relationSkin2Tex Old peptides with new faces: A new strategy to develop non-toxic antimicrobial textiles for healthcare applications.
dc.relationCOVALENT AND NON-COVALENT STRATEGIES FOR SURFACE MODIFICATION OF DIFFERENT TEXTILE MATERIALS WITH ANTIMICROBIAL PROPERTIES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectl-Cysteine (l-Cys)pt_PT
dc.subjectAntimicrobial applicationspt_PT
dc.subjectMedical textilespt_PT
dc.subjectAtopic dermatitis (AD)pt_PT
dc.subjectStaphylococcus aureusapt_PT
dc.titleAntimicrobial and antioxidant surface modification toward a new silk-fibroin (SF)-l-Cysteine material for skin disease managementpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSkin2Tex Old peptides with new faces: A new strategy to develop non-toxic antimicrobial textiles for healthcare applications.
oaire.awardTitleCOVALENT AND NON-COVALENT STRATEGIES FOR SURFACE MODIFICATION OF DIFFERENT TEXTILE MATERIALS WITH ANTIMICROBIAL PROPERTIES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FEBB-BIO%2F113671%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F91444%2F2012/PT
oaire.citation.endPage559pt_PT
oaire.citation.startPage552pt_PT
oaire.citation.titleApplied Surface Sciencept_PT
oaire.citation.volume364pt_PT
oaire.fundingStream5876-PPCDTI
person.familyNameSequeira Nogueira
person.familyNameGranadeiro
person.familyNameMouro
person.familyNameGouveia
person.givenNameFrederico Álvaro
person.givenNameLuiza Breitenfeld
person.givenNameCláudia
person.givenNameIsabel Cristina
person.identifierH-2141-2015
person.identifier274116
person.identifier626131
person.identifier.ciencia-id7119-F02C-91CE
person.identifier.ciencia-idE71F-B2E5-D657
person.identifier.ciencia-id5711-86D0-A54B
person.identifier.orcid0000-0003-2229-8920
person.identifier.orcid0000-0001-8550-1645
person.identifier.orcid0000-0003-2148-9602
person.identifier.orcid0000-0003-3290-9529
person.identifier.ridP-1852-2015
person.identifier.ridK-1651-2014
person.identifier.scopus-author-id56194664600
person.identifier.scopus-author-id34467456600
person.identifier.scopus-author-id24328741500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationa2024ec6-6edb-47e5-b8a0-594066a5036c
relation.isAuthorOfPublication.latestForDiscovery18065beb-b866-4756-9530-fd651e347eb7
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