Publication
Antimicrobial and antioxidant surface modification toward a new silk-fibroin (SF)-l-Cysteine material for skin disease management
dc.contributor.author | Nogueira, Frederico | |
dc.contributor.author | Granadeiro, Luiza Breitenfeld | |
dc.contributor.author | Mouro, Cláudia | |
dc.contributor.author | Gouveia, Isabel C. | |
dc.date.accessioned | 2019-11-04T12:26:14Z | |
dc.date.available | 2019-11-04T12:26:14Z | |
dc.date.issued | 2016 | |
dc.description.abstract | A novel dressing material – silk fibroin fabric (SF)-l-Cysteine (l-Cys) – is here developed to be used asstandard treatment for atopic dermatitis (AD), which combines comfort, thermic, and tensile strengthproperties of silk materials with antioxidant and antimicrobial effects of l-Cys. A careful understand-ing about the linking strategies is needed in order not to compromise the bioavailability of l-Cys anddeplenish its bioactivity. Durability was also addressed through washing cycles and compared with hos-pital requirements, according to international Standard EN ISO 105-C06:2010. The present research alsoanalyze the interactions between Staphylococcus aureus and SF-l-Cys under simulating conditions of ADand demonstrated the effectiveness of a double covalent grafting, with the importance of SF tyrosine(Tyr) covalent linkage with l-Cys (SF-g-l-Cys/Tyr-g-l-Cys) even after several washing cycles, twenty five,whereas for a disposable application a single covalent mechanism of grafting l-Cys proved to be suffi-cient (SF-g-l-Cys). Results showed effective antimicrobial activities exhibiting higher inhibition ratios of98.65% for SF-g-l-Cys after 5 washing cycles, whereas 97.55% for SF-g-l-Cys/Tyr-g-l-Cys after 25 washingcycles, both at pH 9.5 grafting strategy. Furthermore, it is also reported a non-protumoral effect of l-Cys. Anew advance is herein achieved at the world of medical antimicrobial textiles tailored to address woundmoisture environment and exudate self-cleaning, which may open novel applications as complementarytherapy for AD disease. | pt_PT |
dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
dc.identifier.doi | 10.1016/j.apsusc.2015.12.174 | pt_PT |
dc.identifier.uri | http://hdl.handle.net/10400.6/7496 | |
dc.language.iso | eng | pt_PT |
dc.relation | Skin2Tex Old peptides with new faces: A new strategy to develop non-toxic antimicrobial textiles for healthcare applications. | |
dc.relation | COVALENT AND NON-COVALENT STRATEGIES FOR SURFACE MODIFICATION OF DIFFERENT TEXTILE MATERIALS WITH ANTIMICROBIAL PROPERTIES | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
dc.subject | l-Cysteine (l-Cys) | pt_PT |
dc.subject | Antimicrobial applications | pt_PT |
dc.subject | Medical textiles | pt_PT |
dc.subject | Atopic dermatitis (AD) | pt_PT |
dc.subject | Staphylococcus aureusa | pt_PT |
dc.title | Antimicrobial and antioxidant surface modification toward a new silk-fibroin (SF)-l-Cysteine material for skin disease management | pt_PT |
dc.type | journal article | |
dspace.entity.type | Publication | |
oaire.awardTitle | Skin2Tex Old peptides with new faces: A new strategy to develop non-toxic antimicrobial textiles for healthcare applications. | |
oaire.awardTitle | COVALENT AND NON-COVALENT STRATEGIES FOR SURFACE MODIFICATION OF DIFFERENT TEXTILE MATERIALS WITH ANTIMICROBIAL PROPERTIES | |
oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FEBB-BIO%2F113671%2F2009/PT | |
oaire.awardURI | info:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F91444%2F2012/PT | |
oaire.citation.endPage | 559 | pt_PT |
oaire.citation.startPage | 552 | pt_PT |
oaire.citation.title | Applied Surface Science | pt_PT |
oaire.citation.volume | 364 | pt_PT |
oaire.fundingStream | 5876-PPCDTI | |
person.familyName | Sequeira Nogueira | |
person.familyName | Granadeiro | |
person.familyName | Mouro | |
person.familyName | Gouveia | |
person.givenName | Frederico Álvaro | |
person.givenName | Luiza Breitenfeld | |
person.givenName | Cláudia | |
person.givenName | Isabel Cristina | |
person.identifier | H-2141-2015 | |
person.identifier | 274116 | |
person.identifier | 626131 | |
person.identifier.ciencia-id | 7119-F02C-91CE | |
person.identifier.ciencia-id | E71F-B2E5-D657 | |
person.identifier.ciencia-id | 5711-86D0-A54B | |
person.identifier.orcid | 0000-0003-2229-8920 | |
person.identifier.orcid | 0000-0001-8550-1645 | |
person.identifier.orcid | 0000-0003-2148-9602 | |
person.identifier.orcid | 0000-0003-3290-9529 | |
person.identifier.rid | P-1852-2015 | |
person.identifier.rid | K-1651-2014 | |
person.identifier.scopus-author-id | 56194664600 | |
person.identifier.scopus-author-id | 34467456600 | |
person.identifier.scopus-author-id | 24328741500 | |
project.funder.identifier | http://doi.org/10.13039/501100001871 | |
project.funder.identifier | http://doi.org/10.13039/501100001871 | |
project.funder.name | Fundação para a Ciência e a Tecnologia | |
project.funder.name | Fundação para a Ciência e a Tecnologia | |
rcaap.rights | openAccess | pt_PT |
rcaap.type | article | pt_PT |
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