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Trends in protein-based biosensor assemblies for drug screening and pharmaceutical kinetic studies

2014-08-18Journal article Open access
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dc.contributor.authorGonçalves, Ana M
dc.contributor.authorPedro, Augusto
dc.contributor.authorSantos, F M
dc.contributor.authorMartins, Luís M
dc.contributor.authorBaptista, Cláudio
dc.contributor.authorQueiroz, João
dc.contributor.authorPassarinha, L A
dc.date.accessioned2019-12-03T14:23:40Z
dc.date.available2019-12-03T14:23:40Z
dc.date.issued2014-08-18
dc.description.abstractThe selection of natural and chemical compounds for potential applications in new pharmaceutical formulations constitutes a time-consuming procedure in drug screening. To overcome this issue, new devices called biosensors, have already demonstrated their versatility and capacity for routine clinical diagnosis. Designed to perform analytical analysis for the detection of a particular analyte, biosensors based on the coupling of proteins to amperometric and optical devices have shown the appropriate selectivity, sensibility and accuracy. During the last years, the exponential demand for pharmacokinetic studies in the early phases of drug development, along with the need of lower molecular weight detection, have led to new biosensor structure materials with innovative immobilization strategies. The result has been the development of smaller, more reproducible biosensors with lower detection limits, and with a drastic reduction in the required sample volumes. Therefore in order to describe the main achievements in biosensor fields, the present review has the main aim of summarizing the essential strategies used to generate these specific devices, that can provide, under physiological conditions, a credible molecule profile and assess specific pharmacokinetic parameters.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/molecules190812461pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/7659
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectBiosensorpt_PT
dc.subjectPharmacokineticspt_PT
dc.subjectEnzymespt_PT
dc.subjectAntibodiespt_PT
dc.subjectPlasma proteinspt_PT
dc.subjectNano-compositespt_PT
dc.titleTrends in protein-based biosensor assemblies for drug screening and pharmaceutical kinetic studiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage12485pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage12461pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume19pt_PT
person.familyNameQuaresma Henriques Pedro
person.familyNameMilhano dos Santos
person.familyNameMaia Baptista
person.familyNameQueiroz
person.familyNamePaulino Passarinha
person.givenNameAugusto
person.givenNameFátima Raquel
person.givenNameCláudio Jorge
person.givenNameJoão
person.givenNameLuís António
person.identifierhttps://scholar.google.com/citations?user=oer44UoAAAAJ&hl=pt-PT&oi=ao
person.identifierhttps://scholar.google.pt/citations?user=hFKOd_QAAAAJ&hl=pt-PT&oi=ao
person.identifierhttps://www.researchgate.net/profile/Luis_Passarinha
person.identifier.ciencia-id7111-B2BE-336D
person.identifier.ciencia-idD01A-2666-0E20
person.identifier.ciencia-id5115-FCBD-A31F
person.identifier.ciencia-id931E-B66D-E341
person.identifier.ciencia-id621B-74BF-F9A7
person.identifier.orcid0000-0001-8194-6022
person.identifier.orcid0000-0002-4041-1504
person.identifier.orcid0000-0002-5658-5445
person.identifier.orcid0000-0002-3096-8325
person.identifier.orcid0000-0001-6910-7576
person.identifier.ridL-3104-2014
person.identifier.scopus-author-id54080426100
person.identifier.scopus-author-id23097426600
person.identifier.scopus-author-id7003705645
person.identifier.scopus-author-id12445439600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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