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Preparation of end-capped pH-sensitive mesoporous silica nanocarriers for on-demand drug delivery

2014-09-16Journal article Restricted access
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dc.contributor.authorMoreira, André
dc.contributor.authorGaspar, Vítor Manuel Abreu
dc.contributor.authorCosta, Elisabete C.
dc.contributor.authorDiogo, Duarte Miguel de Melo
dc.contributor.authorMachado, Paulo Filipe Brito
dc.contributor.authorPaquete, Catarina
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.date.accessioned2018-03-20T14:43:04Z
dc.date.available2018-03-20T14:43:04Z
dc.date.issued2014-09-16
dc.description.abstractNanocarriers with a pH responsive behavior are receiving an ever growing attention due to their potential for promoting on-demand drug release and thus increase the therapeutic effectiveness of anti-tumoral pharmaceutics. However, the majority of these systems require costly, time-consuming and complex chemical modifications of materials or drugs to synthesize nanoparticles with pH triggered release. Herein, the development of dual drug loaded pH-responsive mesoporous silica nanoparticles (MSNs) with a calcium carbonate-based coating is presented as an effective alternative. This innovative approach allowed the loading of a non-steroidal anti-inflammatory drug (Ibuprofen) and Doxorubicin, with high efficiency. The resulting dual drug loaded MSNs have spherical morphology and a mean size of 171 nm. Our results indicate that under acidic conditions the coating disassembles and the drugs are rapidly released, whereas at physiologic pH the release is slower and gradually increases with time. Furthermore, an improved cytotoxic effect was obtained for Doxorubicin–Ibuprofen MSNs coated with CaCO3 in comparison with non-coated particles. The cytotoxic effect of dual loaded carbonate coated particles, was similar to that of Doxorubicin + Ibuprofen free drug administration at 72 h, even with the delivery of a significantly lower amount of drug by MSNs-CaCO3. These results suggest that the carbonate coating of MSNs is a promising approach to create a pH-sensitive template for a delivery system with application in cancer therapy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMoreira, A.F., Gaspar, V.M., Costa, E.C., De Melo-Diogo, D., Machado, P., Paquete, C.M. e Correia, I.J. (2014) “Preparation of end-capped pH-sensitive mesoporous silica nanocarriers for on-demand drug delivery”, European Journal of Pharmaceutics and Biopharmaceutics, Vol. 88 (3), pp. 1012-1025pt_PT
dc.identifier.doi10.1016/j.ejpb.2014.09.002pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4659
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationIsolation and Purification of Plasmid DNA for Cancer Therapy
dc.relationStrategic Project - UI 709 - 2011-2012
dc.relation2014 - Strategic Project
dc.relationBIOSYNTHESIS AND PURIFICATION OF MINICIRCLE DNA FOR APPLICATION IN DIABETES CELL-SPECIFIC GENE THERAPY
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0939641114002732pt_PT
dc.subjectCalcium carbonatept_PT
dc.subjectCancer therapypt_PT
dc.subjectCo-deliverypt_PT
dc.subjectInorganic nanoparticlespt_PT
dc.subjectPH responsivept_PT
dc.subjectProstate cancerpt_PT
dc.titlePreparation of end-capped pH-sensitive mesoporous silica nanocarriers for on-demand drug deliverypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleIsolation and Purification of Plasmid DNA for Cancer Therapy
oaire.awardTitleStrategic Project - UI 709 - 2011-2012
oaire.awardTitle2014 - Strategic Project
oaire.awardTitleBIOSYNTHESIS AND PURIFICATION OF MINICIRCLE DNA FOR APPLICATION IN DIABETES CELL-SPECIFIC GENE THERAPY
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FEBB-BIO%2F114320%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FSAU%2FUI0709%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FSAU%2FUI0709%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBD%2F80402%2F2011/PT
oaire.citation.endPage1025pt_PT
oaire.citation.startPage1012pt_PT
oaire.citation.titleEuropean Journal of Pharmaceutics and Biopharmaceuticspt_PT
oaire.citation.volume88pt_PT
oaire.fundingStream5876-PPCDTI
oaire.fundingStream6820 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamFARH
person.familyNameMoreira
person.familyNameGaspar
person.familyNameda Rocha Costa
person.familyNameMiguel de Melo Diogo
person.familyNamePaquete
person.familyNameJoaquim Sobreira Correia
person.givenNameAndré Ferreira
person.givenNameVítor
person.givenNameElisabete Cristina
person.givenNameDuarte
person.givenNameCatarina
person.givenNameIlídio
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person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-0604-2506
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person.identifier.orcid0000-0002-0490-0095
person.identifier.orcid0000-0001-9984-3603
person.identifier.orcid0000-0002-1511-3732
person.identifier.orcid0000-0003-1613-9675
person.identifier.ridB-1602-2017
person.identifier.ridA-6615-2016
person.identifier.scopus-author-id56401521300
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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