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IR780 loaded gelatin‐PEG coated gold core silica shell nanorods for cancer‐targeted photothermal/photodynamic therapy

2021Journal article Open access
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dc.contributor.authorGonçalves, Ariana
dc.contributor.authorRodrigues, Ana Carolina Félix
dc.contributor.authorFernandes, Natanael
dc.contributor.authorDiogo, Duarte de Melo
dc.contributor.authorFerreira, Paula
dc.contributor.authorMoreira, André F.
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2023-01-03T12:01:47Z
dc.date.available2025-01-03T01:30:20Z
dc.date.issued2021
dc.description.abstractGold core silica shell (AuMSS) nanorods present excellent physicochemical proper-ties that allow their application as photothermal and drug delivery agents. Herein,AuMSS nanorods were dual‐functionalized with Polyethylene glycol methyl ether(PEG‐CH3) and Gelatin (GEL) to enhance both the colloidal stability and uptake byHeLa cancer cells. Additionally, the AuMSS nanorods were combined for the firsttime with IR780 (a heptamethine cyanine molecule) and its photothermal and pho-todynamic capacities were determined. The obtained results reveal that the en-capsulation of IR780 (65 μg per AuMSS mg) increases the photothermal conversionefficiency of AuMSS nanorods by 10%, and this enhanced heat generation wasmaintained even after three irradiation cycles with a NIR (808 nm) laser. Moreover,the IR780‐loaded AuMSS/T‐PEG‐CH3/T‐GEL presented≈2‐times higher uptake inHeLa cells, when compared to the non‐coated counterparts, and successfullymediated the light‐triggered generation of reactive oxygen species. Overall, thecombination of photodynamic and photothermal therapy mediated by IR780‐loadedAuMSS/T‐PEG‐CH3/T‐GEL nanorods effectively promoted the ablation of HeLacancer cells.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1002/bit.27996pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/12573
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherwileypt_PT
dc.relationDevelopment of multifunctional Gold Core Silica Shell nanomedicines for the immune/chemo/photothermal therapy of breast cancer
dc.relationHealth Sciences Research Centre
dc.subjectGelatinpt_PT
dc.subjectGold core silica shell nanoparticlespt_PT
dc.subjectIR780pt_PT
dc.subjectPEG‐CH3pt_PT
dc.subjectPhotodynamic therapypt_PT
dc.subjectPhotothermal therapypt_PT
dc.titleIR780 loaded gelatin‐PEG coated gold core silica shell nanorods for cancer‐targeted photothermal/photodynamic therapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of multifunctional Gold Core Silica Shell nanomedicines for the immune/chemo/photothermal therapy of breast cancer
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F144680%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.citation.conferencePlaceEUApt_PT
oaire.citation.endPage656pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage644pt_PT
oaire.citation.titleBiotechnology and Bioengineeringpt_PT
oaire.citation.volume119pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameGonçalves
person.familyNameFélix Rodrigues
person.familyNameFernandes
person.familyNamede Melo-Diogo
person.familyNameCalvinho
person.familyNameMoreira
person.familyNameCorreia
person.givenNameAriana
person.givenNameAna Carolina
person.givenNameNatanael
person.givenNameDuarte
person.givenNamePaula Cristina Nunes Ferreira
person.givenNameAndré Ferreira
person.givenNameIlídio Joaquim Sobreira
person.identifierC2z5x04AAAAJ
person.identifier1161643
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id031A-CDE6-6457
person.identifier.ciencia-id3D14-BE84-E5CD
person.identifier.ciencia-id2315-CC5A-3DBB
person.identifier.ciencia-id9C10-9BD8-634E
person.identifier.ciencia-idA119-FFB8-0899
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0001-7408-1331
person.identifier.orcid0000-0002-5493-8331
person.identifier.orcid0000-0002-7737-9288
person.identifier.orcid0000-0001-9984-3603
person.identifier.orcid0000-0003-3393-4427
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id57202076016
person.identifier.scopus-author-id56266511300
person.identifier.scopus-author-id55321888200
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctO copyright foi cedido à editorapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationf3e03091-7605-4411-9fce-5e2edc49d269
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