Repository logo
 
Publication

A poly(ε-caprolactone) device for sustained release of an anti-glaucoma drug

2011-02-04Journal article Restricted access
Simple item page
dc.contributor.authorNatu, Mădălina
dc.contributor.authorGaspar, Manuel
dc.contributor.authorRibeiro, Carlos
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.contributor.authorSilva, Daniela
dc.contributor.authorSousa, Hermínio C. de
dc.contributor.authorGil, Maria
dc.date.accessioned2018-03-19T10:49:11Z
dc.date.available2018-03-19T10:49:11Z
dc.date.issued2011-02-04
dc.description.abstractImplantable dorzolamide-loaded discs were prepared by blending poly(ε-caprolactone), PCL, with poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide), Lu. By blending, crystallinity, water uptake and mass loss were modified relative to the pure polymers. Burst was diminished by coating the discs with a PCL shell. All samples presented burst release except PCL-coated samples that showed controlled release during 18 days. For PCL-coated samples, barrier control of diffusion coupled with partition control from the core slowed down the release, while for 50/50 Lu/PCL-coated samples, the enhancement in the porosity of the core diminished partition control of drug release. Nonlinear regression analysis suggested that a degradation model fully describes the release curve considering a triphasic release mechanism: the instantaneous diffusion (burst), diffusion and polymer degradation stages. The MTT test indicated that the materials are not cytotoxic for corneal endothelial cells. A good in vitro–in vivo correlation was obtained, with similar amounts of drug released in vitro and in vivo. The discs decreased intraocular pressure (IOP) in normotensive rabbit eyes by 13.0% during 10 days for PCL-coated and by 13.0% during 4 days for 50/50 Lu/PCL-coated samples. The percentages of IOP decrease are similar to those obtained by dorzolamide eyedrop instillation (11.0%).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNatu, M.V., Gaspar, M.N., Ribeiro, C.A., Correia, I.J., Silva, D., de Sousa, H.C. e Gil, M.H. (2011) “A poly(ε-caprolactone) device for sustained release of an anti-glaucoma drug”, Biomedical Materials, Vol. 6(2): 025003pt_PT
dc.identifier.doi10.1088/1748-6041/6/2/025003pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4629
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherIOPSCIENCEpt_PT
dc.relationINTRAOCULAR CONTROLLED RELEASE SYSTEM FOR OPTHALMOLOGIC APPLICATIONS
dc.relationESTUDOS ESTRUTURAIS, MECANÍSTICOS E FUNCIONAIS DE CANAIS DE CÁLCIO MEMBRANARES
dc.relation.publisherversionhttp://iopscience.iop.org/article/10.1088/1748-6041/6/2/025003pt_PT
dc.subjectPCLpt_PT
dc.subjectAnti-glaucomapt_PT
dc.subjectSustained releasept_PT
dc.titleA poly(ε-caprolactone) device for sustained release of an anti-glaucoma drugpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleINTRAOCULAR CONTROLLED RELEASE SYSTEM FOR OPTHALMOLOGIC APPLICATIONS
oaire.awardTitleESTUDOS ESTRUTURAIS, MECANÍSTICOS E FUNCIONAIS DE CANAIS DE CÁLCIO MEMBRANARES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POSI/SFRH%2FBD%2F30198%2F2006/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F19776%2F2004/PT
oaire.citation.startPage025003pt_PT
oaire.citation.titleBiomedical Materialspt_PT
oaire.citation.volume6pt_PT
oaire.fundingStreamPOSI
person.familyNameFontes Ribeiro
person.familyNameJoaquim Sobreira Correia
person.familyNameCipriano de Sousa
person.familyNameGil
person.givenNameCarlos
person.givenNameIlídio
person.givenNameHermínio José
person.givenNameMaria Helena
person.identifierUMbJ1KMAAAAJ
person.identifierA-8783-2008
person.identifier.ciencia-id2917-516B-C827
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-idF61E-906D-549E
person.identifier.ciencia-id0E10-A6F7-901B
person.identifier.orcid0000-0002-9707-4895
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0002-2629-7805
person.identifier.orcid0000-0003-0657-7751
person.identifier.ridB-7729-2018
person.identifier.scopus-author-id6701724909
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id57201225798
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication15dddcdc-b69a-4054-b3db-c28631d40ad9
relation.isAuthorOfPublicationf2c3e779-34a2-4309-950a-80687664c6ad
relation.isAuthorOfPublicationdd6ca8c6-7b2f-4f7d-b2a0-8bd9bfdcc888
relation.isAuthorOfPublication676a8017-743a-4f22-93be-4915428f318d
relation.isAuthorOfPublication.latestForDiscovery15dddcdc-b69a-4054-b3db-c28631d40ad9
relation.isProjectOfPublication857e36f1-3741-4332-a792-eaf9f733fe3c
relation.isProjectOfPublication5b739dfa-0333-4e54-b398-ea9d14184056
relation.isProjectOfPublication.latestForDiscovery857e36f1-3741-4332-a792-eaf9f733fe3c

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
2011 Natu BMM.pdf
Size:
650.21 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FCS - DCM | Documentos por Auto-Depósito