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Inorganic-based drug delivery systems for cancer therapy

2020-01-01Book part Open access
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dc.contributor.authorRodrigues, Ana Carolina Félix
dc.contributor.authorAlves, Cátia
dc.contributor.authorLima-Sousa, Rita
dc.contributor.authorMoreira, André F.
dc.contributor.authorDiogo, Duarte de Melo
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2023-01-05T17:33:29Z
dc.date.available2025-01-05T01:30:22Z
dc.date.issued2020-01-01
dc.description.abstractThe aging of the worldwide population has associated an increased incidence and prevalence of several pathologies, such as cancer, skin lesions, and neurological disorders. To improve the therapeutic outcome, researchers have been involved in the development of new disruptive therapeutic products that provide personalized and more efficient healthcare solutions. Among them, inorganic nanoparticles such as those made of gold, silica, or graphene-based materials have been used by researchers and clinicians for cancer therapy. Inorganic nanoparticles present unique size- and shape-dependent physicochemical and optical properties that in conjugation with high loading capacities prompted their application as therapeutics, drug delivery vehicles, and imaging agents. Additionally, these structures can also be conjugated with targeting moieties or stealthing agents to further improve their accumulation in the tumor tissue and, consequently, enhance their therapeutic effect. Herein, the advances attained in the application of inorganic nanoparticles in tumor targeting, imaging, photothermal therapy, and delivery of bioactive molecules, such as drugs (e.g., doxorubicin), genetic material (e.g., DNA, siRNA), and immunotherapy mediators are discussed as well as its limitations and toxicity issues.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/B978-0-12-819666-3.00010-9pt_PT
dc.identifier.isbn978-0-12-819666-3
dc.identifier.urihttp://hdl.handle.net/10400.6/12587
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationHealth Sciences Research Centre
dc.relationDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
dc.subjectCancer theragnosticspt_PT
dc.subjectDrug delivery systemspt_PT
dc.subjectGold nanomaterialspt_PT
dc.subjectGraphene oxidept_PT
dc.subjectInorganic nanoparticlespt_PT
dc.subjectMesoporous silica nanostructurespt_PT
dc.titleInorganic-based drug delivery systems for cancer therapypt_PT
dc.typebook part
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109482%2F2015/PT
oaire.citation.endPage316pt_PT
oaire.citation.startPage283pt_PT
oaire.citation.titleAdvances And Avenues In The Development Of Novel Carriers For Bioactives And Biological Agentspt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_CENTRO
person.familyNameFélix Rodrigues
person.familyNameAlves
person.familyNameSousa
person.familyNameMoreira
person.familyNamede Melo-Diogo
person.familyNameCorreia
person.givenNameAna Carolina
person.givenNameCátia Gomes
person.givenNameAna Rita Lima
person.givenNameAndré Ferreira
person.givenNameDuarte
person.givenNameIlídio Joaquim Sobreira
person.identifier1161643
person.identifierC2z5x04AAAAJ
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person.identifier.ciencia-id3D14-BE84-E5CD
person.identifier.ciencia-id8317-7EF2-24C8
person.identifier.ciencia-idBD19-68AA-7099
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-id9C10-9BD8-634E
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-5493-8331
person.identifier.orcid0000-0001-7066-3051
person.identifier.orcid0000-0003-4764-1967
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0001-9984-3603
person.identifier.orcid0000-0003-1613-9675
person.identifier.ridB-1125-2019
person.identifier.scopus-author-id57202076016
person.identifier.scopus-author-id57201213407
person.identifier.scopus-author-id57201215315
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id56266511300
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctOs direitos foram cedidos à editorapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typebookPartpt_PT
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