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Human CD8+ T Cells in Asthma: Possible Pathways and Roles for NK-Like Subtypes

2016Journal article Open access
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dc.contributor.authorLourenço, Olga
dc.contributor.authorFonseca, A M
dc.contributor.authorBarata, Luis Taborda
dc.date.accessioned2020-02-19T09:42:06Z
dc.date.available2020-02-19T09:42:06Z
dc.date.issued2016
dc.description.abstractAsthma affects approximately 300 million people worldwide and is the most common chronic lung disease, which usually is associated with bronchial inflammation. Most research has focused upon the role of CD4+ T cells, and relatively few studies have addressed the phenotypic and functional roles of CD8+ T cell types and subtypes. Human NK-like CD8+ T cells may involve cells that have been described as CD8+CD28-, CD8+CD28-CD57+, CD8+CD27-, or CD8+ effector memory (TEM) cells, among other. However, most of the data that are available regarding these various cell types were obtained in murine models did not thoroughly characterize these cells with phenotypically or functionally or did not involve asthma-related settings. Nevertheless, one may conceptualize three principal roles for human NK-like CD8+ T cells in asthma: disease-promoting, regulatory, and/or tissue repair. Although evidence for some of these roles is scarce, it is possible to extrapolate some data from overlapping or related CD8+ T cell phenotypes, with caution. Clearly, further research is warranted, namely in terms of thorough functional and phenotypic characterization of human NK-like CD8+ T cells in human asthma of varying severity.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3389/fimmu.2016.00638pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/9355
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectAsthmapt_PT
dc.subjectCells - CD8pt_PT
dc.subjectCells - CD28pt_PT
dc.subjectCells - CD27pt_PT
dc.subjectCells - CD57pt_PT
dc.subjectHumanpt_PT
dc.subjectNK-likept_PT
dc.subjectT cellspt_PT
dc.titleHuman CD8+ T Cells in Asthma: Possible Pathways and Roles for NK-Like Subtypespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.citation.startPage638pt_PT
oaire.citation.titleFrontiers in Immunologypt_PT
oaire.citation.volume7pt_PT
oaire.fundingStream5876
person.familyNameLourenço
person.familyNameLoureiro Fonseca
person.familyNameTaborda Barata
person.givenNameOlga
person.givenNameAna Mafalda
person.givenNameLuis
person.identifierH-3836-2012
person.identifier104007
person.identifier.ciencia-id6618-1C4C-D1B7
person.identifier.ciencia-idA61D-657A-6DD0
person.identifier.ciencia-id1E1F-8A43-055B
person.identifier.orcid0000-0002-8401-5976
person.identifier.orcid0000-0003-1118-5525
person.identifier.orcid0000-0001-6649-8890
person.identifier.scopus-author-id15128160500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationc890c74a-abc1-4910-aa70-f0da7b4ad902
relation.isAuthorOfPublication34cfbd2d-5537-4aba-8552-3e2e4d48b473
relation.isAuthorOfPublication3f1ad371-56e3-4fda-9409-748e355a0de1
relation.isAuthorOfPublication.latestForDiscovery3f1ad371-56e3-4fda-9409-748e355a0de1
relation.isProjectOfPublicationcb4688cf-40da-4197-9eb0-c55bad699ad3
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