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Immobilization of bacteriophage in wound-dressing nanostructure

2017Journal article Open access
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dc.contributor.authorNogueira, Frederico
dc.contributor.authorKarumidze, Natia
dc.contributor.authorKusradze, Ia
dc.contributor.authorGoderdzishvili, Marina
dc.contributor.authorTeixeira, Pilar
dc.contributor.authorGouveia, Isabel C.
dc.date.accessioned2019-11-04T11:32:52Z
dc.date.available2019-11-04T11:32:52Z
dc.date.issued2017
dc.description.abstractOpportunistic bacteria that cause life-threatening infections are still a central problem associated with a healthcare setting. Bacteriophage capsid immobilization on nanostructured polymers maximizes its tail exposure and looks promising in applications toward skin-infections as alternative to antibiotics standardly used. The main goal of this work was to investigate the covalent immobilization of vB_Pae_Kakheti25 bacteriophage capsid on polycaprolactone (PCL) nanofibers (non-woven textile), as a potential effective antimicrobial, laundry resistant and non-toxic dressing for biomedical use. Surface analyses showed that the immobilization of vB_Pae_Kakheti25 bacteriophage capsid on PCL nanofibres oriented bacteriophage tails to interact with bacteria. Furthermore, antimicrobial assays showed a very effective 6 log bacterial reduction, which was equivalent to 99.9999%, after immediate and 2 hours of contact, even following 25 washing cycles (due to covalent bond). The activity of PCL-vB_Pae_Kakheti25 against P. aeruginosa was immediate and its reduction was complete.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.nano.2017.08.008pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/7491
dc.language.isoengpt_PT
dc.relationCOVALENT AND NON-COVALENT STRATEGIES FOR SURFACE MODIFICATION OF DIFFERENT TEXTILE MATERIALS WITH ANTIMICROBIAL PROPERTIES
dc.subjectBacteriophagespt_PT
dc.subjectAntimicrobial agentspt_PT
dc.subjectSurface immobilizationpt_PT
dc.subjectElectrospinningpt_PT
dc.subjectPseudomonas aeruginosapt_PT
dc.titleImmobilization of bacteriophage in wound-dressing nanostructurept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCOVALENT AND NON-COVALENT STRATEGIES FOR SURFACE MODIFICATION OF DIFFERENT TEXTILE MATERIALS WITH ANTIMICROBIAL PROPERTIES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F91444%2F2012/PT
oaire.citation.endPage2484pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage2475pt_PT
oaire.citation.titleNanomedicine: Nanotechnology, Biology and Medicinept_PT
oaire.citation.volume13pt_PT
person.familyNameSequeira Nogueira
person.familyNameKarumidze
person.familyNameAraújo Teixeira
person.familyNameGouveia
person.givenNameFrederico Álvaro
person.givenNameNatia
person.givenNameMaria do Pilar
person.givenNameIsabel Cristina
person.identifierH-2141-2015
person.identifier626131
person.identifier.ciencia-id7119-F02C-91CE
person.identifier.ciencia-idB01C-A9B6-9397
person.identifier.ciencia-id5711-86D0-A54B
person.identifier.orcid0000-0003-2229-8920
person.identifier.orcid0000-0002-3069-7123
person.identifier.orcid0000-0003-2735-6608
person.identifier.orcid0000-0003-3290-9529
person.identifier.ridK-1651-2014
person.identifier.scopus-author-id56194664600
person.identifier.scopus-author-id24328741500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationfcb53947-35ab-422e-bc67-b834ee7331d4
relation.isAuthorOfPublicationfc4186f7-787d-4ed7-9955-b44b31885050
relation.isAuthorOfPublicationa2024ec6-6edb-47e5-b8a0-594066a5036c
relation.isAuthorOfPublication.latestForDiscoveryfc4186f7-787d-4ed7-9955-b44b31885050
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