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Development of a novel hydrogel for skin regeneration

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dc.contributor.authorMiguel, Sónia P.
dc.contributor.authorRibeiro, MP.
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.date.accessioned2018-04-13T09:29:58Z
dc.date.available2018-04-13T09:29:58Z
dc.date.issued2014
dc.description.abstractSkin lesions are traumatic events that lead to increased fluid loss, infections, scars formation and the appearance of immunocompromised regions. The loss of skin integrity can result in significant physiological imbalances and disability or even death. So far, different wound dressings have been developed. Among them, hydrogels are the most applied. Herein, a thermoresponsive hydrogel was produced using chitosan and agarose formed at body temperature (37°C), in order to verify their applicability in the treatment of wounds. Hydrogel bactericidal activity, biocompatibility, morphology, porosity and wettability were characterized by confocal microscopy, MTS assay and SEM. The attained results revealed that hydrogel has a pore size (90–400 µm) compatible with cellular internalization and proliferation. A bactericidal activity was observed for hydrogels containing more than 188 µg/mL of chitosan. The results obtained demonstrated that this 3D network has the suitable properties for improving the healing process of cutaneous wounds.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMiguel, S., Ribeiro, M.P. e Correia, I.J. (2014) "Development of a novel hydrogel for skin regeneration", LAP LAMBERT Academic Publishing.pt_PT
dc.identifier.isbn978-3-659-59717-6
dc.identifier.urihttp://hdl.handle.net/10400.6/4739
dc.language.isoengpt_PT
dc.peerreviewednopt_PT
dc.publisherLambert Academic Publishingpt_PT
dc.relation.publisherversionhttps://www.lap-publishing.com/catalog/details/store/gb/book/978-3-659-59717-6/development-of-a-novel-hydrogel-for-skin-regeneration?search=3659597171pt_PT
dc.subjectHydrogelpt_PT
dc.subjectSkinpt_PT
dc.titleDevelopment of a novel hydrogel for skin regenerationpt_PT
dc.typebook
dspace.entity.typePublication
person.familyNamePereira Miguel
person.familyNameRibeiro
person.familyNameJoaquim Sobreira Correia
person.givenNameSónia Alexandra
person.givenNameMaximiano
person.givenNameIlídio
person.identifierGX0L2QAAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id1A13-ABC0-C32C
person.identifier.ciencia-idBD11-6497-FD37
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0001-6357-8115
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id26658759200
person.identifier.scopus-author-id7003557499
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typebookpt_PT
relation.isAuthorOfPublication3956033a-4abf-439b-a4fd-25c5bd9d8e7a
relation.isAuthorOfPublication3fe7a59f-e867-4bed-bb6e-7d7631330af5
relation.isAuthorOfPublicationf2c3e779-34a2-4309-950a-80687664c6ad
relation.isAuthorOfPublication.latestForDiscovery3956033a-4abf-439b-a4fd-25c5bd9d8e7a

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