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Stilbenes from Vine Extracts: Therapeutic Potential and Mechanisms

2025-08-26Artigo científico Acesso aberto
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datacite.subject.fosCiências Médicas::Ciências da Saúde
dc.contributor.authorBrás, Luís P.
dc.contributor.authorLuís, Ângelo
dc.contributor.authorChatel, Gregory
dc.contributor.authorSocorro, Sílvia
dc.contributor.authorDuarte, Ana Paula
dc.contributor.editorVisioli, Francesco
dc.date.accessioned2026-02-06T12:01:55Z
dc.date.available2026-02-06T12:01:55Z
dc.date.issued2025-08-26
dc.description.abstractThe wine industry represents a significant economic sector; however, it generates large volumes of waste that can be valorized due to the presence of bioactive compounds, particularly stilbenes. These naturally occurring stilbenes exhibit remarkable potential in the prevention and treatment of various diseases, including cardioprotection, neuroprotection, antidiabetic properties, anti-inflammatory activity, and cancer prevention and therapy. This review discusses biosynthesis, structures, extraction methods, and mechanisms of action of stilbenes, with a particular emphasis on cancer prevention and treatment. Evidence from in vitro, in vivo, and clinical studies demonstrate that stilbenes modulate multiple molecular pathways by promoting apoptosis, inhibiting cell proliferation, and regulating inflammation, oxidative stress, and metabolism. However, the clinical application of stilbenes is limited by their low bioavailability. To overcome this, pharmaceutical formulations have been developed to enhance their stability and bioavailability, reduce side effects, and improve target interactions. These advances are expected to increase the therapeutic efficacy of stilbenes. Furthermore, information on the health benefits of less common stilbenes remains limited, highlighting the need for further research on these compounds.
dc.identifier.citationBrás, L.P.; Luís, Â.; Chatel, G.; Socorro, S.; Duarte, A.P. Stilbenes from Vine Extracts: Therapeutic Potential and Mechanisms. Int. J. Mol. Sci. 2025, 26, 8269. https:// doi.org/10.3390/ijms26178269
dc.identifier.doi10.3390/ijms26178269
dc.identifier.issn1422-0067
dc.identifier.other40943191
dc.identifier.urihttp://hdl.handle.net/10400.6/19862
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationHealth Sciences Research Centre [UIDB/00709/2020]
dc.relationCICS-UBI [UIDP/00709/2020]
dc.relationCentro de Investigação em Ciências da Saúde da Universidade da Beira Interior [DL57/2016/CP1354/CT0010]
dc.relationVITAE - Valorization of viticulturalwaste: novel methodological approaches to exploit the anticancer properties of bioactive compounds [PRT/BD/154423/2022]
dc.relation.hasversionhttps://www.mdpi.com/1422-0067/26/17/8269
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectWaste Viticulture
dc.subjectExtraction
dc.subjectStilbenes
dc.subjectBiological Activities
dc.titleStilbenes from Vine Extracts: Therapeutic Potential and Mechanismseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre [UIDB/00709/2020]
oaire.awardTitleCICS-UBI [UIDP/00709/2020]
oaire.awardTitleCentro de Investigação em Ciências da Saúde da Universidade da Beira Interior [DL57/2016/CP1354/CT0010]
oaire.awardTitleVITAE - Valorization of viticulturalwaste: novel methodological approaches to exploit the anticancer properties of bioactive compounds [PRT/BD/154423/2022]
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Programático/UIDP%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/DL 57%2F2016/DL 57%2F2016%2FCP1354%2FCT0010/PT
oaire.awardURIhttps://sciproj.ptcris.pt/99518DFA
oaire.citation.titleInternational Journal of Molecular Sciences
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Programático
oaire.fundingStreamDL 57/2016
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameBrás
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person.familyNameChatel
person.familyNameSocorro
person.familyNameDuarte
person.givenNameLuís Porfírio
person.givenNameÂngelo Filipe Santos
person.givenNameGregory
person.givenNameSílvia Cristina da Cruz Marques
person.givenNameAna Paula
person.identifierhttps://scholar.google.pt/citations?user=PA3L_h8AAAAJ&hl=pt-PT
person.identifier1255684
person.identifier.ciencia-id801D-2DB0-C932
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person.identifier.ciencia-idBC15-D376-80FE
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person.identifier.orcid0000-0003-3333-5977
person.identifier.ridB-5904-2009
person.identifier.scopus-author-id23097994600
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project.funder.nameFundação para a Ciência e a Tecnologia
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